A dual role of Cdk2 in DNA damage response

Once it was believed that Cdk2 was the master regulator of S phase entry. Gene knockout mouse studies of cell cycle regulators revealed that Cdk2 is dispensable for S phase initiation and progression whereby Cdk1 can compensate for the loss of Cdk2. Nevertheless, recent evidence indicates that Cdk2...

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Bibliographic Details
Published inCell division Vol. 4; no. 1; p. 9
Main Authors Satyanarayana, Ande, Kaldis, Philipp
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 18.05.2009
BioMed Central
BMC
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Summary:Once it was believed that Cdk2 was the master regulator of S phase entry. Gene knockout mouse studies of cell cycle regulators revealed that Cdk2 is dispensable for S phase initiation and progression whereby Cdk1 can compensate for the loss of Cdk2. Nevertheless, recent evidence indicates that Cdk2 is involved in cell cycle independent functions such as DNA damage repair. Whether these properties are unique to Cdk2 or also being compensated by other Cdks in the absence of Cdk2 is under extensive investigation. Here we review the emerging new role of Cdk2 in DNA damage repair and also discuss how the loss of Cdk2 impacts the G1/S phase DNA damage checkpoint.
Bibliography:SourceType-Other Sources-1
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ISSN:1747-1028
1747-1028
DOI:10.1186/1747-1028-4-9