Mechanics rules cell biology

Cells in the musculoskeletal system are subjected to various mechanical forces in vivo. Years of research have shown that these mechanical forces, including tension and compression, greatly influence various cellular functions such as gene expression, cell proliferation and differentiation, and secr...

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Bibliographic Details
Published inBMC sports science, medicine & rehabilitation Vol. 2; no. 1; p. 16
Main Authors Wang, James Hc, Li, Bin
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 08.07.2010
BioMed Central
BMC
Subjects
Analysis
Cytology
Gene expression
Human biology
Review
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Summary:Cells in the musculoskeletal system are subjected to various mechanical forces in vivo. Years of research have shown that these mechanical forces, including tension and compression, greatly influence various cellular functions such as gene expression, cell proliferation and differentiation, and secretion of matrix proteins. Cells also use mechanotransduction mechanisms to convert mechanical signals into a cascade of cellular and molecular events. This mini-review provides an overview of cell mechanobiology to highlight the notion that mechanics, mainly in the form of mechanical forces, dictates cell behaviors in terms of both cellular mechanobiological responses and mechanotransduction.
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ISSN:2052-1847
1758-2555
1758-2555
2052-1847
DOI:10.1186/1758-2555-2-16