Attenuation by dextromethorphan on the higher liability to morphine-induced reward, caused by prenatal exposure of morphine in rat offspring

Co-administration of dextromethorphan (DM) with morphine during pregnancy and throughout lactation has been found to reduce morphine physical dependence and tolerance in rat offspring. No evidence was presented, however, for the effect of DM co-administered with morphine during pregnancy on morphine...

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Published inJournal of biomedical science Vol. 16; no. 1; p. 106
Main Authors Wu, Ling-Yi, Chen, Jain-Fang, Tao, Pao-Luh, Huang, Eagle Yi-Kung
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 25.11.2009
BioMed Central
BMC
Subjects
Analgesics, Opioid - administration & dosage
Animals
Behavior, Animal
Dextromethorphan - administration & dosage
Drug Combinations
Drug Tolerance
Excitatory Amino Acid Antagonists - administration & dosage
Female
Male
Morphine - administration & dosage
Morphine Dependence - prevention & control
Pregnancy
Pregnancy, Animal
Prenatal Exposure Delayed Effects
Rats
Rats, Sprague-Dawley
Sex Factors
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Summary:Co-administration of dextromethorphan (DM) with morphine during pregnancy and throughout lactation has been found to reduce morphine physical dependence and tolerance in rat offspring. No evidence was presented, however, for the effect of DM co-administered with morphine during pregnancy on morphine-induced reward and behavioral sensitization (possibly related to the potential to induce morphine addiction) in morphine-exposed offspring. Conditioned place preference and locomotor activity tests revealed that the p60 male offspring of chronic morphine-treated female rats were more vulnerable to morphine-induced reward and behavioral sensitization. The administration of a low dose of morphine (1 mg/kg, i.p.) in these male offspring also increased the dopamine and serotonin turnover rates in the nucleus accumbens, which implied that they were more sensitive to morphine. Co-administration of DM with morphine in the dams prevented this adverse effect of morphine in the offspring rats. Thus, DM may possibly have a great potential in the prevention of higher vulnerability to psychological dependence of morphine in the offspring of morphine-addicted mothers.
Bibliography:ObjectType-Article-1
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ISSN:1423-0127
1021-7770
1423-0127
DOI:10.1186/1423-0127-16-106