Primary Cilia in Tumor Biology: The Primary Cilium as a Therapeutic Target in Cholangiocarcinoma

Cilia are microtubule-based organelles, which are ubiquitously expressed in epithelial cells. Cholangiocytes, the epithelial cells lining the biliary tree, have primary cilia extending from their apical plasma membrane into the ductal lumen, where the cilia function as multisensory organelles transd...

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Published inCurrent drug targets Vol. 18; no. 8; p. 958
Main Authors Gradilone, Sergio A, Pisarello, Maria J Lorenzo, LaRusso, Nicholas F
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.01.2017
Subjects
Bile Duct Neoplasms - drug therapy
Bile Duct Neoplasms - pathology
Cholangiocarcinoma - drug therapy
Cholangiocarcinoma - metabolism
Cholangiocarcinoma - pathology
Cilia - drug effects
Cilia - metabolism
Cilia - pathology
Epithelial Cells - cytology
Epithelial Cells - metabolism
Humans
MAP Kinase Signaling System - drug effects
Molecular Targeted Therapy
cholangiocyte
ciliotherapy
bile duct cancer
Primary cilia
cholangiocarcinoma
HDAC6
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Summary:Cilia are microtubule-based organelles, which are ubiquitously expressed in epithelial cells. Cholangiocytes, the epithelial cells lining the biliary tree, have primary cilia extending from their apical plasma membrane into the ductal lumen, where the cilia function as multisensory organelles transducing environmental cues into the cell interior. The decrease or loss of primary cilia has been described in several malignancies, including cholangiocarcinoma, suggesting that the loss of cilia is a common occurrence in neoplastic transformation. In this short review, we describe the expression of cilia in several cancers, explore the mechanisms and consequences of ciliary loss, and discuss the potential use of the primary cilia as therapeutic targets.
ISSN:1873-5592
DOI:10.2174/1389450116666150223162737