B Lymphocytes Are Predictors of Insulin Resistance in Women with Gestational Diabetes Mellitus

Backgroud: The present study aimed to investigate the association between immune cells and gestational diabetes mellitus (GDM) and identify a reasonable predictor of insulin resistance in women with GDM. The clinical and biochemical characteristics of 124 women with GDM and 168 healthy pregnant wome...

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Published inEndocrine, metabolic & immune disorders drug targets Vol. 19; no. 3; p. 358
Main Authors Zhuang, Yan, Zhang, Jin, Li, Yiwei, Gu, Hongqin, Zhao, Jinyan, Sun, Ya, Wang, Rencheng, Zhang, Chunyan, Chen, Wen, Weng, Jianrong, Qi, Lan, Lu, Huifang, Zhang, Jiarong, Liu, Qin, He, Yinyan, Xu, Xianming
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.01.2019
Subjects
Adult
B-Lymphocytes - immunology
B-Lymphocytes - metabolism
Diabetes, Gestational - blood
Diabetes, Gestational - diagnosis
Diabetes, Gestational - immunology
Female
Humans
Insulin Resistance - physiology
Predictive Value of Tests
Pregnancy
GDM
IgA
immune
B lymphocytes
inflammation
flow cytometry
insulin resistance
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Abstract Backgroud: The present study aimed to investigate the association between immune cells and gestational diabetes mellitus (GDM) and identify a reasonable predictor of insulin resistance in women with GDM. The clinical and biochemical characteristics of 124 women with GDM and 168 healthy pregnant women were compared. The percentage of immune cells in the blood of the subjects was analyzed by flow cytometry. Pearson's correlation analysis revealed the correlation between the percentage of B lymphocytes and insulin resistance. A cutoff point was determined for the percentage of B lymphocytes, based on insulin resistance, using receiver operating characteristic (ROC) curves. Compared to the healthy pregnant women, the percentages of B lymphocytes and IgA produced by B-cells were significantly different in women with GDM. The percentage of B lymphocytes was positively related to insulin resistance.The number of 14.05% of B lymphocytes was an optimal cutoff point that predicted the insulin resistance in women with GDM. The percentage of B lymphocytes was positively associated with insulin resistance, and hence, might serve as an appropriate predictor of insulin resistance in women with GDM.
AbstractList Backgroud: The present study aimed to investigate the association between immune cells and gestational diabetes mellitus (GDM) and identify a reasonable predictor of insulin resistance in women with GDM. The clinical and biochemical characteristics of 124 women with GDM and 168 healthy pregnant women were compared. The percentage of immune cells in the blood of the subjects was analyzed by flow cytometry. Pearson's correlation analysis revealed the correlation between the percentage of B lymphocytes and insulin resistance. A cutoff point was determined for the percentage of B lymphocytes, based on insulin resistance, using receiver operating characteristic (ROC) curves. Compared to the healthy pregnant women, the percentages of B lymphocytes and IgA produced by B-cells were significantly different in women with GDM. The percentage of B lymphocytes was positively related to insulin resistance.The number of 14.05% of B lymphocytes was an optimal cutoff point that predicted the insulin resistance in women with GDM. The percentage of B lymphocytes was positively associated with insulin resistance, and hence, might serve as an appropriate predictor of insulin resistance in women with GDM.
Author Liu, Qin
Gu, Hongqin
He, Yinyan
Xu, Xianming
Sun, Ya
Li, Yiwei
Qi, Lan
Lu, Huifang
Wang, Rencheng
Zhang, Jin
Zhang, Chunyan
Chen, Wen
Weng, Jianrong
Zhang, Jiarong
Zhuang, Yan
Zhao, Jinyan
Author_xml – sequence: 1
  givenname: Yan
  surname: Zhuang
  fullname: Zhuang, Yan
  organization: Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100, Haining Road, Shanghai 200080, China
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  givenname: Jin
  surname: Zhang
  fullname: Zhang, Jin
  organization: Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100, Haining Road, Shanghai 200080, China
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  givenname: Yiwei
  surname: Li
  fullname: Li, Yiwei
  organization: Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100, Haining Road, Shanghai 200080, China
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  givenname: Hongqin
  surname: Gu
  fullname: Gu, Hongqin
  organization: Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100, Haining Road, Shanghai 200080, China
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  givenname: Jinyan
  surname: Zhao
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  surname: Sun
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  organization: Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100, Haining Road, Shanghai 200080, China
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  givenname: Rencheng
  surname: Wang
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  organization: Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100, Haining Road, Shanghai 200080, China
– sequence: 8
  givenname: Chunyan
  surname: Zhang
  fullname: Zhang, Chunyan
  organization: Department of Obstetrics and Gynecology, Shangyou Maternal and Child Care Service Center, No.9 Shuinan Avenue, Ganzhou City, Jiangxi Province 341200, China
– sequence: 9
  givenname: Wen
  surname: Chen
  fullname: Chen, Wen
  organization: Department of Obstetrics and Gynecology, Fuluan Maternal and Child Care Service Center, No.2 Kaiyuan Road, Jingdezhen City, Jiangxi Province 333400, China
– sequence: 10
  givenname: Jianrong
  surname: Weng
  fullname: Weng, Jianrong
  organization: Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100, Haining Road, Shanghai 200080, China
– sequence: 11
  givenname: Lan
  surname: Qi
  fullname: Qi, Lan
  organization: Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100, Haining Road, Shanghai 200080, China
– sequence: 12
  givenname: Huifang
  surname: Lu
  fullname: Lu, Huifang
  organization: Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100, Haining Road, Shanghai 200080, China
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  givenname: Jiarong
  surname: Zhang
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  organization: Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100, Haining Road, Shanghai 200080, China
– sequence: 14
  givenname: Qin
  surname: Liu
  fullname: Liu, Qin
  organization: The Wistar Institution, 19104, Philadelphia, United States
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  givenname: Yinyan
  surname: He
  fullname: He, Yinyan
  organization: Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100, Haining Road, Shanghai 200080, China
– sequence: 16
  givenname: Xianming
  surname: Xu
  fullname: Xu, Xianming
  organization: Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100, Haining Road, Shanghai 200080, China
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Keywords GDM
IgA
immune
B lymphocytes
inflammation
flow cytometry
insulin resistance
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Snippet Backgroud: The present study aimed to investigate the association between immune cells and gestational diabetes mellitus (GDM) and identify a reasonable...
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SubjectTerms Adult
B-Lymphocytes - immunology
B-Lymphocytes - metabolism
Diabetes, Gestational - blood
Diabetes, Gestational - diagnosis
Diabetes, Gestational - immunology
Female
Humans
Insulin Resistance - physiology
Predictive Value of Tests
Pregnancy
Title B Lymphocytes Are Predictors of Insulin Resistance in Women with Gestational Diabetes Mellitus
URI https://www.ncbi.nlm.nih.gov/pubmed/30621567
Volume 19
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