B Lymphocytes Are Predictors of Insulin Resistance in Women with Gestational Diabetes Mellitus

• Published in: Endocrine, metabolic & immune disorders drug targets Vol. 19; no. 3; p. 358
• Main Authors: Zhuang, Yan, Zhang, Jin, Li, Yiwei, Gu, Hongqin, Zhao, Jinyan, Sun, Ya, Wang, Rencheng, Zhang, Chunyan, Chen, Wen, Weng, Jianrong, Qi, Lan, Lu, Huifang, Zhang, Jiarong, Liu, Qin, He, Yinyan, Xu, Xianming
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2019
• Subjects: Adult; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; Diabetes, Gestational - blood; Diabetes, Gestational - diagnosis; Diabetes, Gestational - immunology; Female; Humans; Insulin Resistance - physiology; Predictive Value of Tests; Pregnancy; GDM; IgA; immune; B lymphocytes; inflammation; flow cytometry; insulin resistance
• ISSN: 2212-3873
• DOI: 10.2174/1871530319666190101130300

Backgroud: The present study aimed to investigate the association between immune cells and gestational diabetes mellitus (GDM) and identify a reasonable predictor of insulin resistance in women with GDM. The clinical and biochemical characteristics of 124 women with GDM and 168 healthy pregnant women were compared. The percentage of immune cells in the blood of the subjects was analyzed by flow cytometry. Pearson's correlation analysis revealed the correlation between the percentage of B lymphocytes and insulin resistance. A cutoff point was determined for the percentage of B lymphocytes, based on insulin resistance, using receiver operating characteristic (ROC) curves. Compared to the healthy pregnant women, the percentages of B lymphocytes and IgA produced by B-cells were significantly different in women with GDM. The percentage of B lymphocytes was positively related to insulin resistance.The number of 14.05% of B lymphocytes was an optimal cutoff point that predicted the insulin resistance in women with GDM. The percentage of B lymphocytes was positively associated with insulin resistance, and hence, might serve as an appropriate predictor of insulin resistance in women with GDM.