Effect of multivitamin and multimineral supplements on morbidity from infections in older people (MAVIS trial): pragmatic, randomised, double blind, placebo controlled trial

• Published in: BMJ Vol. 331; no. 7512; pp. 324 - 327
• Main Authors: Avenell, Alison, Campbell, Marion K, Cook, Jonathan A, Hannaford, Philip C, Kilonzo, Mary M, McNeill, Geraldine, Milne, Anne C, Ramsay, Craig R, Seymour, D Gwyn, Stephen, Audrey I, Vale, Luke D
• Format: Journal Article
• Language: English
• Published: London British Medical Journal Publishing Group 06.08.2005; British Medical Association; BMJ Publishing Group LTD; BMJ Publishing Group; BMJ Publishing Group Ltd
• Edition: International edition
• Subjects: Aged; Aged, 80 and over; Antibiotics; Binomials; Biological and medical sciences; Clinical trials; Communities; Diaries; Dietary supplements; Double-Blind Method; Family Practice - statistics & numerical data; Female; General aspects; General practice; Health services; Hospital admissions; Hospitals; Humans; Immune system; Infection - drug therapy; Infections; Male; Medical sciences; Minerals; Minerals - administration & dosage; Morbidity; Nursing care; Nursing homes; Nutrition; Older adults; Older people; Patient Acceptance of Health Care - statistics & numerical data; Patient Compliance; Placebos; Pragmatism; Primary Care; Primary health care; Quality of Life; Questionnaires; Risk Factors; Studies; Tablets; Vitamin C; Vitamin E; Vitamins; Vitamins - administration & dosage; United Kingdom > UK; Scotland; Human; Epidemiology; Morbidity; Pragmatics; Infection; Medicine; Multivitamin; Randomised controlled trial; Double blind study; Clinical trial; Trace element (nutrient); Supplementation; Elderly
• ISSN: 0959-8138; 0959-8146; 1468-5833; 1756-1833
• DOI: 10.1136/bmj.331.7512.324

Objective To examine whether supplementation with multivitamins and multiminerals influences self reported days of infection, use of health services, and quality of life in people aged 65 or over. Design Randomised, placebo controlled trial, with blinding of participants, outcome assessors, and investigators. Setting Communities associated with six general practices in Grampian, Scotland. Participants 910 men and women aged 65 or over who did not take vitamins or minerals. Interventions Daily multivitamin and multimineral supplementation or placebo for one year. Main outcome measures Primary outcomes were contacts with primary care for infections, self reported days of infection, and quality of life. Secondary outcomes included antibiotic prescriptions, hospital admissions, adverse events, and compliance. Results Supplementation did not significantly affect contacts with primary care and days of infection per person (incidence rate ratio 0.96, 95% confidence interval 0.78 to 1.19 and 1.07, 0.90 to 1.27). Quality of life was not affected by supplementation. No statistically significant findings were found for secondary outcomes or subgroups. Conclusion Routine multivitamin and multimineral supplementation of older people living at home does not affect self reported infection related morbidity. Trial registration ISRCTN: 66376460.