Chemical changes of human knee joint menisci in various stages of degeneration

Human knee joint menisci graded according to degenerative alterations were submitted to chemical analysis. Normal menisci contained 72% water, 0.12% DNA, 22% collagen, and 0.8% total glycosaminoglycans with the following glycosaminoglycan distribution pattern: 40% chondroitin 6-sulphate, 10-20% chon...

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Published inAnnals of the rheumatic diseases Vol. 43; no. 4; pp. 635 - 640
Main Authors Herwig, J, Egner, E, Buddecke, E
Format Journal Article
LanguageEnglish
Published London BMJ Publishing Group Ltd and European League Against Rheumatism 01.08.1984
BMJ
BMJ Publishing Group LTD
Subjects
Adolescent
Adult
Biological and medical sciences
Body Water - analysis
Cartilage Diseases - metabolism
Cartilage Diseases - pathology
Child
Collagen - analysis
Diseases of the osteoarticular system
DNA - metabolism
Female
Glycosaminoglycans - analysis
Humans
Knee Joint - analysis
Knee Joint - pathology
Male
Medical sciences
Menisci, Tibial - analysis
Menisci, Tibial - pathology
Middle Aged
Osteoarthritis
Knee
Biochemistry
Semilunar cartilage
Osteoarthritis
Diseases of the osteoarticular system
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Summary:Human knee joint menisci graded according to degenerative alterations were submitted to chemical analysis. Normal menisci contained 72% water, 0.12% DNA, 22% collagen, and 0.8% total glycosaminoglycans with the following glycosaminoglycan distribution pattern: 40% chondroitin 6-sulphate, 10-20% chondroitin 4-sulphate, 20-30% dermatan sulphate, and 15% keratan sulphate. The water content increased with increasing degeneration, whereas the collagen and glycosaminoglycan contents decreased with relative increase of chondroitin 6-sulphate.
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PMID:6548109
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ISSN:0003-4967
1468-2060
DOI:10.1136/ard.43.4.635