Familial cavernous malformations in a large French kindred: mapping of the gene to the CCM1 locus on chromosome 7q

• Published in: Journal of neurology, neurosurgery and psychiatry Vol. 63; no. 1; pp. 40 - 45
• Main Authors: Notelet, L, Chapon, F, Khoury, S, Vahedi, K, Chodkiewicz, J P, Courtheoux, P, Iba-Zizen, M T, Cabanis, E A, Lechevalier, B, Tournier-Lasserve, E, Houtteville, J P
• Format: Journal Article Conference Proceeding
• Language: English
• Published: London BMJ Publishing Group Ltd 01.07.1997; BMJ; BMJ Publishing Group LTD; BMJ Group
• Subjects: Adolescent; Adult; Asymptomatic; Biological and medical sciences; brain; Brain - pathology; cavernoma; Chromosome Mapping; Chromosomes; Chromosomes, Human, Pair 7 - genetics; Family; Female; France; Genetic Linkage; genetics; Haplotypes; Hispanic Americans; Humans; Intracranial Arteriovenous Malformations - epidemiology; Intracranial Arteriovenous Malformations - genetics; Intracranial Arteriovenous Malformations - pathology; Lod Score; Magnetic Resonance Imaging; Male; Medical imaging; Medical sciences; Microsatellite Repeats; Neuroimaging; Neurology; Pedigree; Vascular diseases and vascular malformations of the nervous system; vascular malformation; France; Human; Cartography; Intracranial; Nervous system diseases; Genetic inheritance; Linkage; Long arm; Family study; Cardiovascular disease; Chromosome C7; Nuclear magnetic resonance imaging; Cerebral disorder; Cavernous angioma; Vascular disease; French; Central nervous system disease; Genetics; Medical imagery; Adult; Haplotype; Cerebrovascular disease
• ISSN: 0022-3050; 1468-330X
• DOI: 10.1136/jnnp.63.1.40

OBJECTIVES To characterise clinically a large French family affected with cerebral cavernomas and to check for linkage of this condition to chromosome 7. METHODS A family, originating from Normandy and in which five members had undergone surgery for cavernomas, was extended. All members older than 18 were studied clinically and by neuroimaging. Genetic linkage analysis was conducted using 11 polymorphic microsatellite markers located between D7S502 and D7S479. RESULTS The family included three generations. Among the 25 members investigated, 11 had an abnormal cerebral MRI, eight of them being symptomatic, and 12 were asymptomatic with a normal MRI. The status of the two remaining members could not be established on the basis of clinical and MRI data. The family reported shares some striking features with other previously linked families—namely, a high clinical penetrance and the presence of multiple lesions within most of the affected members. A lod score of 4.04 was obtained with marker D7S657 with no recombinant. Significant lod scores were also obtained with D7S524 (Zmax=3.32 at θ=0.00) and D7S630 (Zmax=3.44 at θ=0.00). These results establish linkage of the condition found in this family to chromosome 7. Haplotype analysis strongly suggests that the gene is telomeric to D7S802 and centromeric to D7S479. CONCLUSIONS These data confirm linkage of cerebral cavernous malformations to chromosome 7 in a non-Hispanic family.