Low-grade metabolic acidosis as a driver of chronic disease: a 21st century public health crisis

[...]a low blood pH is typically one of the last surrogate markers to become abnormal in those with low-grade metabolic acidosis.2 This is because the body maintains a normal blood pH at the expense of bicarbonate reserves. [...]once the blood pH falls below 7.4, there is usually acid retention in t...

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Published inOpen heart Vol. 8; no. 2; p. e001730
Main Authors DiNicolantonio, James J, O'Keefe, James
Format Journal Article
LanguageEnglish
Published England British Cardiovascular Society 01.10.2021
BMJ Publishing Group LTD
BMJ Publishing Group
Subjects
Acidosis
Acidosis - complications
Acidosis - diagnosis
Acidosis - metabolism
Ammonia
Cardiovascular Diseases - etiology
Cardiovascular Diseases - metabolism
Chronic Disease
Chronic illnesses
Connective tissue
coronary vessels
Diet
Editorial
Fasting
Humans
Kidneys
Metabolism
myocardial infarction
Protein synthesis
Public Health
Retention
Severity of Illness Index
Urine
vascular malformations
vascular malformations
coronary vessels
myocardial infarction
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Summary:[...]a low blood pH is typically one of the last surrogate markers to become abnormal in those with low-grade metabolic acidosis.2 This is because the body maintains a normal blood pH at the expense of bicarbonate reserves. [...]once the blood pH falls below 7.4, there is usually acid retention in the body and low-grade metabolic acidosis.2 However, the blood pH does not drop below the normal range until metabolic acidosis has become severe. Typically, with low-grade metabolic acidosis, the blood pH drops slightly, as does the bicarbonate levels, but they will still be in the ‘normal’ range. [...]if blood pH and/or bicarbonate levels are at the lower end of normal this is highly suggestive that someone has metabolic acidosis.2 With low-grade metabolic acidosis, the total blood buffering capacity is reduced and thus a greater reliance on muscle, bone and connective tissue will be required for the elimination of additional acid. [...]some individuals can have a normal blood pH level and a fully functioning buffering system in the body, whereas others can have a normal blood pH but their buffering systems are deficient.
Bibliography:SourceType-Other Sources-1
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ObjectType-Editorial-2
ObjectType-Commentary-1
ISSN:2053-3624
2398-595X
2053-3624
DOI:10.1136/openhrt-2021-001730