CRISPR/Cas9: at the cutting edge of hepatology
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 genome engineering has revolutionised biomedical science and we are standing on the cusp of medical transformation. The therapeutic potential of this technology is tremendous, however, its translation to the clinic will be chall...
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Published in | Gut Vol. 66; no. 7; pp. 1329 - 1340 |
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Main Authors | , , , |
Format | Journal Article Book Review |
Language | English |
Published |
England
BMJ Publishing Group LTD
01.07.2017
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Subjects | |
Online Access | Get full text |
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Summary: | Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 genome engineering has revolutionised biomedical science and we are standing on the cusp of medical transformation. The therapeutic potential of this technology is tremendous, however, its translation to the clinic will be challenging. In this article, we review recent progress using this genome editing technology and explore its potential uses in studying and treating diseases of the liver. We discuss the development of new research tools and animal models as well as potential clinical applications, strategies and challenges. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0017-5749 1468-3288 |
DOI: | 10.1136/gutjnl-2016-313565 |