Relationship between air pollution and positivity of RA-related autoantibodies in individuals without established RA: a report on SERA

• Published in: Annals of the rheumatic diseases Vol. 72; no. 12; pp. 2002 - 2005
• Main Authors: Gan, Ryan W, Deane, Kevin D, Zerbe, Gary O, Demoruelle, M Kristen, Weisman, Michael H, Buckner, Jane H, Gregersen, Peter K, Mikuls, Ted R, O'Dell, James R, Keating, Richard M, Holers, V Michael, Norris, Jill M
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and European League Against Rheumatism 01.12.2013; BMJ Publishing Group LTD
• Subjects: Adult; Air pollution; Air Pollution - adverse effects; Air Pollution - analysis; Arthritis, Rheumatoid - etiology; Arthritis, Rheumatoid - genetics; Arthritis, Rheumatoid - immunology; Autoantibodies; Autoantibodies - blood; Autoimmunity; C-Reactive Protein - metabolism; Environmental Monitoring - methods; Epidemiology; Female; Geographic Information Systems; Humans; Hypotheses; Male; Methods; Middle Aged; Mortality; Nitrogen dioxide; Particulate Matter - adverse effects; Particulate Matter - analysis; Particulate Matter - immunology; Pathogenesis; Pollutants; Rheumatoid Arthritis; Rheumatoid Factor; Rheumatoid Factor - blood; Studies; Trends; New York; Autoimmunity; Autoantibodies; Rheumatoid Arthritis; Rheumatoid Factor; Epidemiology
• ISSN: 0003-4967; 1468-2060
• DOI: 10.1136/annrheumdis-2012-202949

Introduction Studies suggest that respiratory exposures including smoking, proximity to traffic and air pollution might be associated with development of rheumatoid arthritis (RA). RA-related autoantibodies are predictive of the development of RA. Objective We evaluated the relationship between RA-related autoantibodies and exposure to particulate matter (PM), a measure of air pollution of interest to health, in individuals without RA. Methods The Studies of the Etiology of Rheumatoid Arthritis (SERA) is a multicentre study following first-degree relatives (FDRs) of a proband with RA. FDRs are without the 1987 ACR (American College of Rheumatology) classifiable RA at enrolment and are followed for the development of RA-related autoimmunity. RA-related autoantibody outcomes as well as tender and swollen joint outcomes were assessed. Exposure to PM was assigned using ambient air pollution monitoring data and interpolated with inverse distance weighting spatial analyses using Geographic Information Systems. PM exposures were linked to FDR's residential zip codes. Results RA-related autoantibodies as well as tender or swollen joints are not associated with ambient PM concentrations. Discussion While other respiratory exposures may be associated with increased risk of RA, our data suggest that ambient PM is not associated with autoantibodies and joint signs among individuals without RA, but at increased risk of developing RA.