Chromatin Remodeling, DNA Damage Repair and Aging

Cells are constantly exposed to a variety of environmental and endogenous conditions causing DNA damage, which is detected and repaired by conserved DNA repair pathways to maintain genomic integrity. Chromatin remodeling is critical in this process, as the organization of eukaryotic DNA into compact...

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Published inCurrent genomics Vol. 13; no. 7; pp. 533 - 547
Main Authors Liu, Baohua, Yip, Raymond Kh, Zhou, Zhongjun
Format Journal Article
LanguageEnglish
Published United Arab Emirates Bentham Science Publishers Ltd 01.11.2012
Bentham Science Publishers
Subjects
Sirtuins
Aging
Epigenetics
Histone modifications
Longevity
DNA double strand break repair
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Summary:Cells are constantly exposed to a variety of environmental and endogenous conditions causing DNA damage, which is detected and repaired by conserved DNA repair pathways to maintain genomic integrity. Chromatin remodeling is critical in this process, as the organization of eukaryotic DNA into compact chromatin presents a natural barrier to all DNA-related events. Studies on human premature aging syndromes together with normal aging have suggested that accumulated damages might lead to exhaustion of resources that are required for physiological functions and thus accelerate aging. In this manuscript, combining the present understandings and latest findings, we focus mainly on discussing the role of chromatin remodeling in the repair of DNA double-strand breaks (DSBs) and regulation of aging.
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ISSN:1389-2029
1875-5488
DOI:10.2174/138920212803251373