Mitochondria and Organismal Longevity

Mitochondria are essential for various biological processes including cellular energy production. The oxidative stress theory of aging proposes that mitochondria play key roles in aging by generating reactive oxygen species (ROS), which indiscriminately damage macromolecules and lead to an age-depen...

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Published inCurrent genomics Vol. 13; no. 7; pp. 519 - 532
Main Authors B. Hwang, Ara, Jeong, Dae-Eun, Lee, Seung-Jae
Format Journal Article
LanguageEnglish
Published United Arab Emirates Bentham Science Publishers Ltd 01.11.2012
Bentham Science Publishers
Subjects
Aging
Dietary restriction
Mitochondria
Reactive oxygen species
Target of rapamycin (TOR)
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Summary:Mitochondria are essential for various biological processes including cellular energy production. The oxidative stress theory of aging proposes that mitochondria play key roles in aging by generating reactive oxygen species (ROS), which indiscriminately damage macromolecules and lead to an age-dependent decline in biological function. However, recent studies show that increased levels of ROS or inhibition of mitochondrial function can actually delay aging and increase lifespan. The aim of this review is to summarize recent findings regarding the role of mitochondria in organismal aging processes. We will discuss how mitochondria contribute to evolutionarily conserved longevity pathways, including mild inhibition of respiration, dietary restriction, and target of rapamycin (TOR) signaling.
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These authors contributed equally to this work.
ISSN:1389-2029
1875-5488
DOI:10.2174/138920212803251427