The molecular mechanisms of glucocorticoids-mediated neutrophil survival

Neutrophil-dominated inflammation plays an important role in many airway diseases including asthma, chronic obstructive pulmonary disease (COPD), bronchiolitis and cystic fibrosis. In cases of asthma where neutrophil-dominated inflammation is a major contributing factor to the disease, treatment wit...

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Bibliographic Details
Published inCurrent drug targets Vol. 12; no. 4; p. 556
Main Authors Saffar, Arash S, Ashdown, Heather, Gounni, Abdelilah S
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.04.2011
Subjects
Animals
Apoptosis
Cell Survival - drug effects
Drug Delivery Systems
Glucocorticoids - adverse effects
Glucocorticoids - pharmacology
Humans
Inflammation - drug therapy
Inflammation - etiology
Inflammation - physiopathology
Lung Diseases - drug therapy
Lung Diseases - physiopathology
Neutrophils - drug effects
Neutrophils - metabolism
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Summary:Neutrophil-dominated inflammation plays an important role in many airway diseases including asthma, chronic obstructive pulmonary disease (COPD), bronchiolitis and cystic fibrosis. In cases of asthma where neutrophil-dominated inflammation is a major contributing factor to the disease, treatment with corticosteroids can be problematic as corticosteroids have been shown to promote neutrophil survival which, in turn, accentuates neutrophilic inflammation. In light of such cases, novel targeted medications must be developed that could control neutrophilic inflammation while still maintaining their antibacterial/anti-fungal properties, thus allowing individuals to maintain effective innate immune responses to invading pathogens. The aim of this review is to describe the molecular mechanisms of neutrophil apoptosis and how these pathways are modulated by glucocorticoids. These new findings are of potential clinical value and provide further insight into treatment of neutrophilic inflammation in lung disease.
ISSN:1873-5592
DOI:10.2174/138945011794751555