Patterns of myocardial inflammation and scarring in sarcoidosis as assessed by cardiovascular magnetic resonance

• Published in: Heart (British Cardiac Society) Vol. 92; no. 3; pp. 399 - 400
• Main Authors: Schulz-Menger, J, Wassmuth, R, Abdel-Aty, H, Siegel, I, Franke, A, Dietz, R, Friedrich, M G
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Cardiovascular Society 01.03.2006; BMJ Publishing Group LTD; BMJ Group
• Subjects: Cardiac arrhythmia; Cardiomyopathies - pathology; Cardiovascular disease; Case-Control Studies; Cicatrix - pathology; contrast enhancement; Coronary vessels; Female; Follow-Up Studies; Heart attacks; Humans; Inflammation; Magnetic Resonance Angiography; magnetic resonance imaging; Male; Middle Aged; myocardial inflammation; Myocarditis - pathology; Sarcoidosis; Sarcoidosis - pathology; Scientific Letter
• ISSN: 1355-6037; 1468-201X
• DOI: 10.1136/hrt.2004.058016

To visualise inflammatory myocardial tissue changes, we assessed global and focal myocardial contrast enhancement in T1 weighted multislice fast spin echo images obtained before and within the first four minutes after application of 0.1 mmol/kg gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA) (Magnevist; Schering AG, Berlin, Germany), as described elsewhere. 2 For the detection of scar tissue, we assessed delayed contrast accumulation with a multislice T1 weighted inversion recovery prepared gradient echo sequence (short axis, inversion time individually optimised, repetition time 5.5 ms, echo time 1.4 ms, slice thickness 10 mm, and no gap) 15 minutes after an additional administration of 0.1 mmol/kg body weight Gd-DTPA. [...]we included patients with preserved LV function.