Adaptive optics imaging of inherited retinal diseases

Adaptive optics (AO) ophthalmoscopy allows for non-invasive retinal phenotyping on a microscopic scale, thereby helping to improve our understanding of retinal diseases. An increasing number of natural history studies and ongoing/planned interventional clinical trials exploit AO ophthalmoscopy both...

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Bibliographic Details
Published inBritish journal of ophthalmology Vol. 102; no. 8; pp. 1028 - 1035
Main Authors Georgiou, Michalis, Kalitzeos, Angelos, Patterson, Emily J, Dubra, Alfredo, Carroll, Joseph, Michaelides, Michel
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group LTD 01.08.2018
BMJ Publishing Group
Subjects
Diabetes
Diabetic retinopathy
Disease
Lasers
Light
Medical imaging
Ophthalmology
Optics
Photoreceptors
Retina
Review
vision
genetics
retina
imaging
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Summary:Adaptive optics (AO) ophthalmoscopy allows for non-invasive retinal phenotyping on a microscopic scale, thereby helping to improve our understanding of retinal diseases. An increasing number of natural history studies and ongoing/planned interventional clinical trials exploit AO ophthalmoscopy both for participant selection, stratification and monitoring treatment safety and efficacy. In this review, we briefly discuss the evolution of AO ophthalmoscopy, recent developments and its application to a broad range of inherited retinal diseases, including Stargardt disease, retinitis pigmentosa and achromatopsia. Finally, we describe the impact of this in vivo microscopic imaging on our understanding of disease pathogenesis, clinical trial design and outcome metrics, while recognising the limitation of the small cohorts reported to date.
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ISSN:0007-1161
1468-2079
DOI:10.1136/bjophthalmol-2017-311328