Structural Chromosome Abnormalities Associated with Obesity: Report of Four New Subjects and Review of Literature

• Published in: Current genomics Vol. 12; no. 3; pp. 190 - 203
• Main Authors: Dasouki, Majed J, Youngs, Erin L, Hovanes, Karine
• Format: Journal Article
• Language: English
• Published: United Arab Emirates Bentham Science Publishers Ltd 01.05.2011
• Subjects: Children; Chromosome aberrations; Congenital defects; DNA; genomics; Growth rate; Heritability; Hyperphagia; Literature reviews; Obesity; Polygenic inheritance; Obesity; fluorescent in situ hybridization; translocation; deletion; chromosome; CNV; aCGH; duplication
• ISSN: 1389-2029; 1875-5488; 1875-5488
• DOI: 10.2174/138920211795677930

Obesity in humans is a complex polygenic trait with high inter-individual heritability estimated at 40 – 70%. Candidate gene, DNA linkage and genome-wide association studies (GWAS) have allowed for the identification of a large set of genes and genomic regions associated with obesity. Structural chromosome abnormalities usually result in congenital anomalies, growth retardation and developmental delay. Occasionally, they are associated with hyperphagia and obesity rather than growth delay. We report four new individuals with structural chromosome abnormalities involving 10q22.3-23.2, 16p11.2 and Xq27.1-q28 chromosomal regions with early childhood obesity and developmental delay. We also searched and summarized the literature for structural chromosome abnormalities reported in association with childhood obesity