Increased prevalence and severity of radiographic hand osteoarthritis in patients with HIV-1 infection associated with metabolic syndrome: data from the cross-sectional METAFIB-OA study

• Published in: Annals of the rheumatic diseases Vol. 75; no. 12; pp. 2101 - 2107
• Main Authors: Tomi, Anne-Laurence, Sellam, Jérémie, Lacombe, Karine, Fellahi, Soraya, Sebire, Manuela, Rey-Jouvin, Caroline, Miquel, Anne, Bastard, Jean-Philippe, Maheu, Emmanuel, Haugen, Ida K, Felson, David T, Capeau, Jacqueline, Girard, Pierre-Marie, Berenbaum, Francis, Meynard, Jean-Luc
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.12.2016; BMJ Publishing Group
• Subjects: Acquired immune deficiency syndrome; Aging; AIDS; Arthritis; Blood; Cross-Sectional Studies; Disease; Drug therapy; Female; Hand Joints - diagnostic imaging; Hand Joints - virology; HIV; HIV Infections - complications; HIV Infections - virology; HIV-1; Human health and pathology; Human immunodeficiency virus; Humans; Infections; Inflammation; Lentivirus; Life Sciences; Male; Metabolic disorders; Metabolic syndrome; Metabolic Syndrome - complications; Metabolic Syndrome - virology; Middle Aged; Obesity; Osteoarthritis; Osteoarthritis - diagnostic imaging; Osteoarthritis - epidemiology; Osteoarthritis - virology; Prevalence; Radiography; Reproducibility; Retroviridae; Rhumatology and musculoskeletal system; Risk Factors; France; United States > US; Hand Osteoarthritis; Osteoarthritis; Infections
• ISSN: 0003-4967; 1468-2060
• DOI: 10.1136/annrheumdis-2016-209262

ObjectiveTo determine radiographic hand osteoarthritis (HOA) prevalence in patients with HIV-1 infection in comparison with the general population and to address whether metabolic syndrome (MetS) may increase the risk of HOA during HIV-1 infection.PatientsPatients with HIV-1 infection and MetS (International Diabetes Federation, IDF criteria) aged 45–65 years were matched by age and gender to HIV-1-infected subjects without MetS and underwent hand radiographs. Framingham OA cohort was used as general population cohort.MethodsRadiographic HOA was defined as Kellgren–Lawrence (KL) score ≥2 on more than one joint. Radiographic severity was assessed by global KL score and number of OA joints. HOA prevalence was compared with that found in the Framingham study, stratified by age and sex. Logistic and linear regression models were used to determine the risk factors of HOA in patients with HIV-1 infection.Results301 patients (88% male, mean age 53.4±5.0 years) were included, 152 with MetS and 149 without it. Overall, HOA prevalence was 55.5% and was higher for those with MetS than those without it (64.5% vs 46.3%, p=0.002). When considering men within each age group, HOA frequency was greater in patients with HIV-1 infection than the general population (all ages: 55.8% vs 38.7%; p<0.0001), due to the subgroup with MetS (64.9%; p<0.0001), as well as the subgroup without MetS, although not significant (46.6%; p=0.09). Risk of HOA was increased with MetS (OR 2.23, 95% 95% CI 1.26% to 3.96%) and age (OR 1.18, 95% CI 1.12 to 1.25). HOA severity was greater for patients with MetS than those without. HOA was not associated with previous or current exposure to protease inhibitors or HIV infection-related markers.ConclusionsHOA frequency is greater in patients with HIV-1 infection, especially those with MetS, than the general population.Trial registration numberNCT02353767.