Recent contributions in the field of the recombinant expression of disulfide bonded proteins in bacteria

The production of heterologous disulfide bonded proteins in bacteria remains a biotechnological challenge. A rapid literature survey results in the identification of some interesting proposals, such as the option of producing functional proteins in the cytoplasm in the presence of sulfhydryl oxidase...

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Bibliographic Details
Published inMicrobial cell factories Vol. 11; no. 1; p. 129
Main Author de Marco, Ario
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 14.09.2012
BioMed Central
BMC
Subjects
Bacteria
Bacteria - genetics
Bacteria - metabolism
Cytoplasm
Development
Disulfides - metabolism
Gene Expression
Genetic aspects
Microbiological synthesis
Oxidases
Physiological aspects
Protein binding
Protein Folding
Recombinant proteins
Recombinant Proteins - chemistry
Recombinant Proteins - genetics
Recombinant Proteins - metabolism
sulfhydryl oxidase
Slovenia
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Summary:The production of heterologous disulfide bonded proteins in bacteria remains a biotechnological challenge. A rapid literature survey results in the identification of some interesting proposals, such as the option of producing functional proteins in the cytoplasm in the presence of sulfhydryl oxidases and isomerases. Furthermore, an ever-increasing number of applications refers to recombinant proteins displayed at the bacterial surface. Time will tell whether these developments will lead to universally accepted laboratory protocols.
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ISSN:1475-2859
1475-2859
DOI:10.1186/1475-2859-11-129