Differences in radiological/HRCT findings in eosinophilic bronchitis and asthma: implication for bronchial responsiveness
Background: Airway hyperresponsiveness in asthmatics is considered to be one of the major consequences of airway inflammation and remodelling. Airway responsiveness is normal in patients with eosinophilic bronchitis (EB), despite eosinophilic inflammation of the airways comparable to that which occu...
Saved in:
Published in | Thorax Vol. 61; no. 1; pp. 41 - 47 |
---|---|
Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
BMJ Publishing Group Ltd and British Thoracic Society
01.01.2006
BMJ BMJ Publishing Group LTD BMJ Group |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Background: Airway hyperresponsiveness in asthmatics is considered to be one of the major consequences of airway inflammation and remodelling. Airway responsiveness is normal in patients with eosinophilic bronchitis (EB), despite eosinophilic inflammation of the airways comparable to that which occurs in asthmatics. Comparisons between asthma and EB should clarify the changes in airway morphology that are related specifically to AHR in asthmatics. Methods: Eighteen asthmatic patients, 15 patients with EB, and 11 healthy subjects were recruited. Airway wall area percentage (WA%), centrilobular prominence, and air trapping were compared using thin slice section computed tomography. Results: WA% was significantly greater in asthmatics than in patients with EB (72 (3.1)% v 54 (2.1)%, p = 0.032) and was similar in EB patients and controls (54 (2.1)% v 57 (1.8)%, p>0.05). Centrilobular prominence and air trapping were similar in EB patients and asthmatics and were significantly greater than in controls. Conclusion: WA% rather than air trapping or centrilobular prominence may be associated with the airway hyperresponsiveness that occurs in asthmatics but not in patients with EB. |
---|---|
Bibliography: | Correspondence to:
Dr C-S Park
Division of Allergy and Respiratory Diseases, Department of Internal Medicine, Soonchunhyang University, Bucheon Hospital, Bucheon Gyeonggi Do 420-021, Republic of Korea; mdcspark@unitel.co.kr PMID:16244090 ark:/67375/NVC-WSCWRV88-1 href:thoraxjnl-61-41.pdf istex:D94960BD68686DDF3B6AF40653B2F1D5C2F01B9A local:0610041 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 S‐WP and J‐SP contributed equally to this work. |
ISSN: | 0040-6376 1468-3296 |
DOI: | 10.1136/thx.2005.044420 |