A Brief Review of circRNA Biogenesis, Detection, and Function
Circular RNA (circRNA) is a non-coding molecule produced through alternative splicingof one or more exons of a gene in the presence of an RNA-induced silencing complex (RISC).Its formation depends on complementary intron sequences on both sides of the circularized sequence.CircRNA functions as a spo...
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| Published in | Current genomics Vol. 22; no. 7; pp. 485 - 495 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United Arab Emirates
Bentham Science Publishers Ltd
31.12.2021
Bentham Science Publishers |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Circular RNA (circRNA) is a non-coding molecule produced through alternative splicingof one or more exons of a gene in the presence of an RNA-induced silencing complex (RISC).Its formation depends on complementary intron sequences on both sides of the circularized sequence.CircRNA functions as a sponge for miRNA, playing the role of the transcriptional regulatoror potential biomarker. It has an impact on fetal growth and on synaptic facilitation in the brain.In this review, we illustrate biogenesis mechanisms, characteristics, and functions of cirRNAs. Wealso summarize methods using sequence feature and RNA next-generation sequencing data for circRNAprediction. Finally, we discuss the state of the research on circRNA in diseases, which willbring new contributions to future disease treatments. |
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| AbstractList | Circular RNA (circRNA) is a non-coding molecule produced through alternative splicing of one or more exons of a gene in the presence of
an
RNA-induced silencing complex (RISC). Its formation depends on complementary intron sequences on both sides of the circularized sequence. CircRNA functions as a sponge for miRNA, playing the role of
the
transcriptional regulator or potential biomarker. It has an impact on fetal growth and on synaptic facilitation in the brain. In this review, we illustrate biogenesis mechanisms, characteristics
,
and functions of cirRNAs.
We also summarize methods using sequence feature and RNA next-generation sequencing data for circRNA prediction
. Finally, we discuss the state of the research on circRNA in diseases, which will bring new contributions to future disease treatments. Circular RNA (circRNA) is a non-coding molecule produced through alternative splicing of one or more exons of a gene in the presence of an RNA-induced silencing complex (RISC). Its formation depends on complementary intron sequences on both sides of the circularized sequence. CircRNA functions as a sponge for miRNA, playing the role of the transcriptional regulator or potential biomarker. It has an impact on fetal growth and on synaptic facilitation in the brain. In this review, we illustrate biogenesis mechanisms, characteristics, and functions of cirRNAs. We also summarize methods using sequence feature and RNA next-generation sequencing data for circRNA prediction. Finally, we discuss the state of the research on circRNA in diseases, which will bring new contributions to future disease treatments. Circular RNA (circRNA) is a non-coding molecule produced through alternative splicing of one or more exons of a gene in the presence of an RNA-induced silencing complex (RISC). Its formation depends on complementary intron sequences on both sides of the circularized sequence. CircRNA functions as a sponge for miRNA, playing the role of the transcriptional regulator or potential biomarker. It has an impact on fetal growth and on synaptic facilitation in the brain. In this review, we illustrate biogenesis mechanisms, characteristics, and functions of cirRNAs. We also summarize methods using sequence feature and RNA next-generation sequencing data for circRNA prediction. Finally, we discuss the state of the research on circRNA in diseases, which will bring new contributions to future disease treatments.Circular RNA (circRNA) is a non-coding molecule produced through alternative splicing of one or more exons of a gene in the presence of an RNA-induced silencing complex (RISC). Its formation depends on complementary intron sequences on both sides of the circularized sequence. CircRNA functions as a sponge for miRNA, playing the role of the transcriptional regulator or potential biomarker. It has an impact on fetal growth and on synaptic facilitation in the brain. In this review, we illustrate biogenesis mechanisms, characteristics, and functions of cirRNAs. We also summarize methods using sequence feature and RNA next-generation sequencing data for circRNA prediction. Finally, we discuss the state of the research on circRNA in diseases, which will bring new contributions to future disease treatments. Circular RNA (circRNA) is a non-coding molecule produced through alternative splicingof one or more exons of a gene in the presence of an RNA-induced silencing complex (RISC).Its formation depends on complementary intron sequences on both sides of the circularized sequence.CircRNA functions as a sponge for miRNA, playing the role of the transcriptional regulatoror potential biomarker. It has an impact on fetal growth and on synaptic facilitation in the brain.In this review, we illustrate biogenesis mechanisms, characteristics, and functions of cirRNAs. Wealso summarize methods using sequence feature and RNA next-generation sequencing data for circRNAprediction. Finally, we discuss the state of the research on circRNA in diseases, which willbring new contributions to future disease treatments. |
| Author | Meng Mei Niannian Liu Ying Liang Le Yang Jianjun Tang Yinglong Wang |
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| Keywords | miRNA sponge complementary intron disease alternative splicing biomarker CircRNA |
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| Snippet | Circular RNA (circRNA) is a non-coding molecule produced through alternative splicingof one or more exons of a gene in the presence of an RNA-induced silencing... Circular RNA (circRNA) is a non-coding molecule produced through alternative splicing of one or more exons of a gene in the presence of an RNA-induced... Circular RNA (circRNA) is a non-coding molecule produced through alternative splicing of one or more exons of a gene in the presence of an RNA-induced... |
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| Title | A Brief Review of circRNA Biogenesis, Detection, and Function |
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