A Brief Review of circRNA Biogenesis, Detection, and Function

Circular RNA (circRNA) is a non-coding molecule produced through alternative splicingof one or more exons of a gene in the presence of an RNA-induced silencing complex (RISC).Its formation depends on complementary intron sequences on both sides of the circularized sequence.CircRNA functions as a spo...

Full description

Saved in:
Bibliographic Details
Published inCurrent genomics Vol. 22; no. 7; pp. 485 - 495
Main Authors Liang, Ying, Liu, Niannian, Yang, Le, Tang, Jianjun, Wang, Yinglong, Mei, Meng
Format Journal Article
LanguageEnglish
Published United Arab Emirates Bentham Science Publishers Ltd 31.12.2021
Bentham Science Publishers
Subjects
miRNA sponge
complementary intron
disease
alternative splicing
biomarker
CircRNA
Online AccessGet full text

Cover

More Information
Summary:Circular RNA (circRNA) is a non-coding molecule produced through alternative splicingof one or more exons of a gene in the presence of an RNA-induced silencing complex (RISC).Its formation depends on complementary intron sequences on both sides of the circularized sequence.CircRNA functions as a sponge for miRNA, playing the role of the transcriptional regulatoror potential biomarker. It has an impact on fetal growth and on synaptic facilitation in the brain.In this review, we illustrate biogenesis mechanisms, characteristics, and functions of cirRNAs. Wealso summarize methods using sequence feature and RNA next-generation sequencing data for circRNAprediction. Finally, we discuss the state of the research on circRNA in diseases, which willbring new contributions to future disease treatments.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1389-2029
1875-5488
DOI:10.2174/1389202922666210331130722