Lens stem cells may reside outside the lens capsule: an hypothesis

• Published in: Theoretical biology and medical modelling Vol. 4; no. 1; p. 22
• Main Authors: Remington, Susann G, Meyer, Rita A
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 08.06.2007; BioMed Central
• Subjects: Animals; Cell Lineage; Cell Proliferation; Crystalline lens; Embryonic stem cells; Epithelium, Corneal - cytology; Lens, Crystalline - cytology; Models, Theoretical; Properties; Stem Cells - cytology; United States
• ISSN: 1742-4682; 1742-4682
• DOI: 10.1186/1742-4682-4-22

In this paper, we consider the ocular lens in the context of contemporary developments in biological ideas. We attempt to reconcile lens biology with stem cell concepts and a dearth of lens tumors.Historically, the lens has been viewed as a closed system, in which cells at the periphery of the lens epithelium differentiate into fiber cells. Theoretical considerations led us to question whether the intracapsular lens is indeed self-contained. Since stem cells generate tumors and the lens does not naturally develop tumors, we reasoned that lens stem cells may not be present within the capsule. We hypothesize that lens stem cells reside outside the lens capsule, in the nearby ciliary body. Our ideas challenge the existing lens biology paradigm. We begin our discussion with lens background information, in order to describe our lens stem cell hypothesis in the context of published data. Then we present the ciliary body as a possible source for lens stem cells, and conclude by comparing the ocular lens with the corneal epithelium.