The effect of high temperatures on cause-specific mortality in England and Wales

• Published in: Occupational and environmental medicine (London, England) Vol. 69; no. 1; pp. 56 - 61
• Main Authors: Gasparrini, Antonio, Armstrong, Ben, Kovats, Sari, Wilkinson, Paul
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd 01.01.2012; BMJ Publishing Group; BMJ Publishing Group LTD
• Subjects: Adolescent; Adult; Age; Age groups; Aged; Aged, 80 and over; Air pollution; Biological and medical sciences; Cardiovascular diseases; Cardiovascular Diseases - mortality; Cause of Death; Causes of death; Child; Child, Preschool; Chronic diseases; Chronic illnesses; Death; Disease; Disease risk; Disorders; England - epidemiology; England and Wales; Environment; Environment. Living conditions; Epidemiology; Female; Heart diseases; Heat; High temperature; Hot Temperature - adverse effects; Humans; Infant; Male; Medical sciences; Middle Aged; Mortality; mortality studies; Myocardial infarction; Myocardial ischemia; Nervous System Diseases - mortality; Observational studies; Ozone; Public health. Hygiene; Public health. Hygiene-occupational medicine; Respiratory Tract Diseases - mortality; Risk; Studies; Thresholds; Time series; Time series analysis; Wales - epidemiology; Young Adult; England; United Kingdom; Great Britain; Europe; Wales; United Kingdom > UK; Human; Temperature; Heat; Health and environment; Mortality; Cause; Time series; Environmental factor; Summer; High temperature; Epidemiology; Public health
• ISSN: 1351-0711; 1470-7926
• DOI: 10.1136/oem.2010.059782

ObjectivesSeveral observational studies have suggested an association between high temperatures and all-cause mortality. However, estimates on more specific mortality outcomes are sparse, and frequently assessed in studies using different analytical methods.MethodsA time series analysis was performed on 10 regions in England and Wales during the summers (June–September) of 1993–2006. Average percentage linear increases in risk for a 1°C increase in temperature above region-specific thresholds and attributable deaths were computed by cause-specific mortality and age groups (0–64, 65–74, 75–84, 85+).ResultsThere was evidence of increased mortality with heat for almost all cause-of-death groups examined, with an overall increase in all-cause mortality of 2.1% (95% CI 1.6% to 2.6%) for a 1°C rise above the regional heat threshold. Among main causes, the steepest increase in risk was for respiratory mortality (+4.1% (3.5% to 4.8%) per 1°C). It was much smaller for cardiovascular causes (+1.8% (1.2% to 2.5%)) and myocardial infarction (+1.1% (0.7% to 1.5%)), but comparatively high for arrhythmias (+5.0% (3.2% to 6.9%)) and pulmonary heart disease (+8.3% (2.7% to 14.3%)). Among non- cardiorespiratory causes, the strongest effects were for genitourinary (+3.8% (2.9% to 4.7%)) and nervous system (+4.6% (3.7% to 5.4%)) disorders. 33.9% of heat deaths were attributable to cardiovascular causes, 24.7% to respiratory causes and 41.3% to all other causes combined.ConclusionsThese results suggest that the risk of heat-related mortality is distributed across a wide range of different causes, and that targeting of preventative actions based on pre-existing disease is unlikely to be efficient.