Hyperuricemia and Cardiovascular Disease

Purine metabolism in the circulatory system yields uric acid as its final oxidation product, which is believed to be linked to the development of gout and kidney stones. Hyperuricemia is closely correlated with cardiovascular disease, metabolic syndrome, and chronic kidney disease, as attested by th...

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Published inCurrent pharmaceutical design Vol. 25; no. 6; p. 700
Main Authors Zhang, Shuangshuang, Wang, Yong, Cheng, Jinsong, Huangfu, Ning, Zhao, Ruochi, Xu, Zhenyu, Zhang, Fuxing, Zheng, Wenyuan, Zhang, Dandan
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.01.2019
Subjects
Cardiovascular Diseases - complications
Cardiovascular Diseases - therapy
Gout
Humans
Hyperuricemia - complications
Hyperuricemia - therapy
Metabolic Syndrome
Uric Acid - blood
metabolic syndrome
chronic kidney disease
Uric acid
cardiovascular diseases
hyperuricaemia
gout
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Abstract Purine metabolism in the circulatory system yields uric acid as its final oxidation product, which is believed to be linked to the development of gout and kidney stones. Hyperuricemia is closely correlated with cardiovascular disease, metabolic syndrome, and chronic kidney disease, as attested by the epidemiological and empirical research. In this review, we summarize the recent knowledge about hyperuricemia, with a special focus on its physiology, epidemiology, and correlation with cardiovascular disease. This review also discusses the possible positive effects of treatment to reduce urate levels in patients with cardiovascular disease and hyperuricemia, which may lead to an improved clinical treatment plan.
AbstractList Purine metabolism in the circulatory system yields uric acid as its final oxidation product, which is believed to be linked to the development of gout and kidney stones. Hyperuricemia is closely correlated with cardiovascular disease, metabolic syndrome, and chronic kidney disease, as attested by the epidemiological and empirical research. In this review, we summarize the recent knowledge about hyperuricemia, with a special focus on its physiology, epidemiology, and correlation with cardiovascular disease. This review also discusses the possible positive effects of treatment to reduce urate levels in patients with cardiovascular disease and hyperuricemia, which may lead to an improved clinical treatment plan.
Author Zhao, Ruochi
Cheng, Jinsong
Huangfu, Ning
Zheng, Wenyuan
Zhang, Shuangshuang
Zhang, Fuxing
Zhang, Dandan
Xu, Zhenyu
Wang, Yong
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  surname: Zhang
  fullname: Zhang, Shuangshuang
  organization: Department of Cardiovascular Medicine, Ningbo First Hospital, Ningbo, Zhejiang 315000, China
– sequence: 2
  givenname: Yong
  surname: Wang
  fullname: Wang, Yong
  organization: Department of Cardiovascular Medicine, Ningbo First Hospital, Ningbo, Zhejiang 315000, China
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  givenname: Jinsong
  surname: Cheng
  fullname: Cheng, Jinsong
  organization: Department of Cardiovascular Medicine, Ningbo First Hospital, Ningbo, Zhejiang 315000, China
– sequence: 4
  givenname: Ning
  surname: Huangfu
  fullname: Huangfu, Ning
  organization: Department of Cardiovascular Medicine, Ningbo First Hospital, Ningbo, Zhejiang 315000, China
– sequence: 5
  givenname: Ruochi
  surname: Zhao
  fullname: Zhao, Ruochi
  organization: Department of Cardiovascular Medicine, Ningbo First Hospital, Ningbo, Zhejiang 315000, China
– sequence: 6
  givenname: Zhenyu
  surname: Xu
  fullname: Xu, Zhenyu
  organization: Department of Cardiovascular Medicine, Ningbo First Hospital, Ningbo, Zhejiang 315000, China
– sequence: 7
  givenname: Fuxing
  surname: Zhang
  fullname: Zhang, Fuxing
  organization: Department of Cardiovascular Medicine, Ningbo First Hospital, Ningbo, Zhejiang 315000, China
– sequence: 8
  givenname: Wenyuan
  surname: Zheng
  fullname: Zheng, Wenyuan
  organization: Department of Cardiovascular Medicine, Ningbo First Hospital, Ningbo, Zhejiang 315000, China
– sequence: 9
  givenname: Dandan
  surname: Zhang
  fullname: Zhang, Dandan
  organization: Department of Pharmacy, The Affiliated Hospital of Medical School of Ningbo University, Ningbo, Zhejiang, China
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Keywords metabolic syndrome
chronic kidney disease
Uric acid
cardiovascular diseases
hyperuricaemia
gout
Language English
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Snippet Purine metabolism in the circulatory system yields uric acid as its final oxidation product, which is believed to be linked to the development of gout and...
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StartPage 700
SubjectTerms Cardiovascular Diseases - complications
Cardiovascular Diseases - therapy
Gout
Humans
Hyperuricemia - complications
Hyperuricemia - therapy
Metabolic Syndrome
Uric Acid - blood
Title Hyperuricemia and Cardiovascular Disease
URI https://www.ncbi.nlm.nih.gov/pubmed/30961478
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