Hyperuricemia and Cardiovascular Disease

Purine metabolism in the circulatory system yields uric acid as its final oxidation product, which is believed to be linked to the development of gout and kidney stones. Hyperuricemia is closely correlated with cardiovascular disease, metabolic syndrome, and chronic kidney disease, as attested by th...

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Published inCurrent pharmaceutical design Vol. 25; no. 6; p. 700
Main Authors Zhang, Shuangshuang, Wang, Yong, Cheng, Jinsong, Huangfu, Ning, Zhao, Ruochi, Xu, Zhenyu, Zhang, Fuxing, Zheng, Wenyuan, Zhang, Dandan
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.01.2019
Subjects
Cardiovascular Diseases - complications
Cardiovascular Diseases - therapy
Gout
Humans
Hyperuricemia - complications
Hyperuricemia - therapy
Metabolic Syndrome
Uric Acid - blood
metabolic syndrome
chronic kidney disease
Uric acid
cardiovascular diseases
hyperuricaemia
gout
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Summary:Purine metabolism in the circulatory system yields uric acid as its final oxidation product, which is believed to be linked to the development of gout and kidney stones. Hyperuricemia is closely correlated with cardiovascular disease, metabolic syndrome, and chronic kidney disease, as attested by the epidemiological and empirical research. In this review, we summarize the recent knowledge about hyperuricemia, with a special focus on its physiology, epidemiology, and correlation with cardiovascular disease. This review also discusses the possible positive effects of treatment to reduce urate levels in patients with cardiovascular disease and hyperuricemia, which may lead to an improved clinical treatment plan.
ISSN:1873-4286
DOI:10.2174/1381612825666190408122557