Mononuclear cell subsets and coronary artery lesions in Kawasaki disease

• Published in: Archives of disease in childhood Vol. 67; no. 6; pp. 706 - 708
• Main Authors: Furukawa, S, Matsubara, T, Yabuta, K
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health 01.06.1992; BMJ
• Subjects: Antigens, CD - analysis; Antigens, Differentiation, Myelomonocytic - analysis; Biological and medical sciences; Blood and lymphatic vessels; Blood Cell Count; Cardiology. Vascular system; Child; Child, Preschool; Coronary Vessels - immunology; Coronary Vessels - pathology; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Female; Humans; Infant; Lipopolysaccharide Receptors; Macrophages - chemistry; Macrophages - immunology; Male; Medical sciences; Monocytes - chemistry; Monocytes - immunology; Mucocutaneous Lymph Node Syndrome - immunology; Mucocutaneous Lymph Node Syndrome - pathology; Human; Monocyte; Pathophysiology; Coronary artery; Cardiovascular disease; Coronary heart disease; Cell subpopulation; Vascular disease; Pathology; Immunological investigation; Serum; Mucocutaneous lymph node syndrome; Child
• ISSN: 0003-9888; 1468-2044
• DOI: 10.1136/adc.67.6.706

The peripheral blood mononuclear cell subsets in patients with Kawasaki disease and coronary artery lesions were investigated. Of the 106 patients 14 had lesions. Patients with Kawasaki disease and coronary artery lesions were found to have increased counts of CD14+ macrophages/monocytes compared with those of patients with Kawasaki disease without lesions. The absolute counts of CD14+ macrophages/monocytes form an important parameter to determine the severity of vascular damage during acute Kawasaki disease.