Lymphadenopathy And Selective Iga Deficiency

Four men presented with unexplained lymphadenopathy. Three had a history of recurrent respiratory infections for several years, and two had lymph node or hepatic granulomas. None was noted to have symptoms of immunodeficiency at the time of presentation. In one patient routine direct immunofluoresce...

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Bibliographic Details
Published inBritish medical journal (Clinical research ed.) Vol. 289; no. 6446; pp. 646 - 647
Main Author French, M. A. H.
Format Journal Article
LanguageEnglish
Published England British Medical Association 15.09.1984
BMJ Publishing Group LTD
Subjects
Adult
Antibodies
Biopsies
Clinical Research
Dysgammaglobulinemia - complications
Granuloma
Humans
IgA Deficiency
Immunoglobulins - analysis
Immunology
Infections
Lymph nodes
Lymphatic diseases
Lymphatic Diseases - etiology
Lymphatic Diseases - immunology
Male
Middle Aged
Physiological immunosuppression
Respiratory tract infections
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Summary:Four men presented with unexplained lymphadenopathy. Three had a history of recurrent respiratory infections for several years, and two had lymph node or hepatic granulomas. None was noted to have symptoms of immunodeficiency at the time of presentation. In one patient routine direct immunofluorescence study failed to detect IgA, and immunological investigations were therefore conducted in the rest. In all patients the findings were similar and characterised by a severe deficiency of IgA. In the absence of a more serious cause selective IgA deficiency may be enough to explain "idiopathic" lymphadenopathy.
Bibliography:ObjectType-Case Study-2
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ISSN:0267-0623
DOI:10.1136/bmj.289.6446.646