The use of a Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study

• Published in: Lipids in health and disease Vol. 7; no. 1; p. 12
• Main Authors: Oben, Julius E, Ngondi, Judith L, Momo, Claudia N, Agbor, Gabriel A, Sobgui, Caroline S Makamto
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 31.03.2008; BioMed Central; BMC
• Subjects: Adult; Anti-Obesity Agents - therapeutic use; Cellulose - therapeutic use; Cissus - chemistry; Dietary Fiber - therapeutic use; Double-Blind Method; Drug Synergism; Female; Humans; Male; Obesity - drug therapy; Phytotherapy; Placebos; Plant Extracts - therapeutic use; Weight Loss - drug effects
• ISSN: 1476-511X; 1476-511X
• DOI: 10.1186/1476-511X-7-12

To evaluate the effects of two formulations, Cissus quadrangularis-only and a Cissus quadrangularis/Irvingia gabonensis combination, on weight loss in overweight and obese human subjects. The study was a 10 week randomized, double-blind, placebo-controlled design involving 72 obese or overweight participants (45.8% male; 54.2% female; ages 21-44; mean age = 29.3). The participants were randomly divided into three equal (n = 24) groups: placebo, Cissus quadrangularis-only, and Cissus quadrangularis/Irvingia gabonensis combination. Capsules containing the placebo or active formulations were administered twice daily before meals; no major dietary changes nor exercises were suggested during the study. A total of six anthropomorphic and serological measurements (body weight, body fat, waist size; total plasma cholesterol, LDL cholesterol, fasting blood glucose level) were taken at baseline and at 4, 8 and 10 weeks. Compared to the placebo group, the two active groups showed a statistically significant difference on all six variables by week 10. The magnitude of the differences was noticeable by week 4 and continued to increase over the trial period. Although the Cissus quadrangularis-only group showed significant reductions on all variables compared to the placebo group, the Cissus quadrangularis/Irvingia gabonensis combination resulted in even larger reductions. This apparently synergistic formulation should prove helpful in the management of obesity and its related complications.