Congenital diaphragmatic hernia: impact of prostanoids in the perioperative period

• Published in: Archives of disease in childhood Vol. 65; no. 9; pp. 994 - 995
• Main Authors: Bos, A P, Tibboel, D, Hazebroek, F W, Stijnen, T, Molenaar, J C
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health 01.09.1990; BMJ; BMJ Publishing Group Ltd; BMJ Publishing Group LTD
• Subjects: 6-Ketoprostaglandin F1 alpha - blood; Airway Resistance; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Birth defects; Body Weight; Control Groups; Departments; Diaphragm; Diaphragmatic hernia; Emergency and intensive care: neonates and children. Prematurity. Sudden death; Hernia; Hernia, Diaphragmatic - blood; Hernia, Diaphragmatic - surgery; Hernias, Diaphragmatic, Congenital; Humans; Hypertension; Indexes; Infant, Newborn; Intensive care medicine; Medical sciences; Neonates; Oxygen - blood; Patients; Pediatrics; Persistent Fetal Circulation Syndrome - blood; Persistent Fetal Circulation Syndrome - complications; Persistent Fetal Circulation Syndrome - surgery; Physiological aspects; Postoperative Period; Prospective Studies; Prostaglandins; Prostanoids; Respiratory Function Tests; Statistical Analysis; Surgery; Thromboxane B2 - blood; Human; Congenital; Pathophysiology; Arachidonic acid derivatives; Cardiovascular disease; Respiratory intensive care; Pulmonary hypertension; Hernia; Leukotriene; Newborn diseases; Newborn; Abdominal disease; Digestive diseases; Diaphragm; Thromboxane
• ISSN: 0003-9888; 1468-2044; 1468-2044
• DOI: 10.1136/adc.65.9.994

A prospective study of 10 neonates with congenital diaphragmatic hernia and five controls to determine the importance of prostanoid concentrations perioperatively and the relation with persistent pulmonary hypertension (PPH) is reported. In neonates with congenital diaphragmatic hernia postoperative concentrations of the vasoconstrictor thromboxane B2 rose significantly and were higher during episodes of PPH; this rise may provoke PPH and subsequent right to left shunting.