Huperzine A, A Potential Therapeutic Agent for Treatment of Alzheimers Disease

• Published in: Current medicinal chemistry Vol. 7; no. 3; pp. 355 - 374
• Main Authors: Bai, D L, Tang, X C, He, X C
• Format: Journal Article
• Language: English
• Published: United Arab Emirates Bentham Science Publishers Ltd 01.03.2000
• Subjects: Absorption; Acetylcholine - physiology; Alkaloids; Alzheimer Disease - drug therapy; Alzheimer's disease; Animals; Brain - drug effects; Brain - physiology; Cholinesterase Inhibitors - chemical synthesis; Cholinesterase Inhibitors - isolation & purification; Cholinesterase Inhibitors - pharmacology; Cholinesterase Inhibitors - therapeutic use; Cholinesterases - drug effects; Cognition - drug effects; Cognition - physiology; donepezil; Drugs, Chinese Herbal - isolation & purification; Drugs, Chinese Herbal - pharmacology; Haplorhini; Humans; huperzine A; Rats; Sesquiterpenes - chemical synthesis; Sesquiterpenes - isolation & purification; Sesquiterpenes - pharmacology; Sesquiterpenes - therapeutic use; Side effects; Stereoisomerism; Structure-Activity Relationship; tacrine

HupA is a potent, reversible and selective inhibitor of AChE with a rapid absorption and penetration into the brain in animal tests. It exhibits memory-enhancing activities in animal and clinical trials. Compared to tacrine and donepezil, HupA possesses a longer duration of action and higher therape...