Huperzine A, A Potential Therapeutic Agent for Treatment of Alzheimers Disease

HupA is a potent, reversible and selective inhibitor of AChE with a rapid absorption and penetration into the brain in animal tests. It exhibits memory-enhancing activities in animal and clinical trials. Compared to tacrine and donepezil, HupA possesses a longer duration of action and higher therape...

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Bibliographic Details
Published inCurrent medicinal chemistry Vol. 7; no. 3; pp. 355 - 374
Main Authors Bai, D L, Tang, X C, He, X C
Format Journal Article
LanguageEnglish
Published United Arab Emirates Bentham Science Publishers Ltd 01.03.2000
Subjects
Absorption
Acetylcholine - physiology
Alkaloids
Alzheimer Disease - drug therapy
Alzheimer's disease
Animals
Brain - drug effects
Brain - physiology
Cholinesterase Inhibitors - chemical synthesis
Cholinesterase Inhibitors - isolation & purification
Cholinesterase Inhibitors - pharmacology
Cholinesterase Inhibitors - therapeutic use
Cholinesterases - drug effects
Cognition - drug effects
Cognition - physiology
donepezil
Drugs, Chinese Herbal - isolation & purification
Drugs, Chinese Herbal - pharmacology
Haplorhini
Humans
huperzine A
Rats
Sesquiterpenes - chemical synthesis
Sesquiterpenes - isolation & purification
Sesquiterpenes - pharmacology
Sesquiterpenes - therapeutic use
Side effects
Stereoisomerism
Structure-Activity Relationship
tacrine
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Summary:HupA is a potent, reversible and selective inhibitor of AChE with a rapid absorption and penetration into the brain in animal tests. It exhibits memory-enhancing activities in animal and clinical trials. Compared to tacrine and donepezil, HupA possesses a longer duration of action and higher therapeutic index, and the peripheral cholinergic side effects are minimal at therapeutic doses. This review article deals with a comprehensive survey of the progress in chemical and pharmacological studies of HupA including the isolation and structure elucidation, pharmacological actions, total synthesis, SAR studies and the future development of HupA. Recently, it has been reported that HupA could reduce neuronal cell death caused by glutamate. The dual bio-activities of HupA would further enhance its value and potentiality as the therapeutic agent for Alzheimers disease.
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ISSN:0929-8673
1875-533X
DOI:10.2174/0929867003375281