Gut-brain signaling in energy homeostasis: the unexpected role of microbiota-derived succinate

In the context of the obesity epidemic, dietary fibers that are found essentially in fruit and vegetables attract more and more attention, since they exert numerous metabolic benefits resulting in the moderation of body weight. Short-chain fatty acids, such as propionate and butyrate, produced throu...

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Bibliographic Details
Published inJournal of endocrinology Vol. 236; no. 2; pp. R105 - R108
Main Authors de Vadder, Filipe, Mithieux, Gilles
Format Journal Article
LanguageEnglish
Published England Bioscientifica Ltd 01.02.2018
Portland Press Ltd The Biochemical Society
BioScientifica
Subjects
Attention
Body weight
Energy balance
Fatty acids
Fermentation
Gluconeogenesis
Homeostasis
Intestinal microflora
Intestine
Life Sciences
Metabolism
Microbiota
Nerves
Neurons and Cognition
Propionic acid
Review
Vegetables
succinate
short-chain fatty acid
intestinal gluconeogenesis
gut–brain axis
glucose metabolism
gut microbiota
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Summary:In the context of the obesity epidemic, dietary fibers that are found essentially in fruit and vegetables attract more and more attention, since they exert numerous metabolic benefits resulting in the moderation of body weight. Short-chain fatty acids, such as propionate and butyrate, produced through their fermentation by the intestinal microbiota, have long been thought to be the mediators of these benefits. In fact, propionate and butyrate were recently shown to activate intestinal gluconeogenesis, a function exerting metabolic benefits via its capacity of signaling to the brain by gastrointestinal nerves. Recently, succinate, the precursor of propionate in the bacterial metabolism, has also been shown to exert signaling properties, including the activation of intestinal gluconeogenesis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0022-0795
1479-6805
DOI:10.1530/JOE-17-0542