Bidirectional association between depressive symptoms and cardiovascular disease in the middle-aged and elderly Chinese: a 5-year longitudinal study

• Published in: BMJ open Vol. 13; no. 7; p. e071175
• Main Authors: Ziwei, Zhang, Hua, Yumeng, Liu, Aiping
• Format: Journal Article
• Language: English
• Published: England British Medical Journal Publishing Group 04.07.2023; BMJ Publishing Group LTD; BMJ Publishing Group
• Series: Original research
• Subjects: Blood tests; Body mass index; cardiology; Cardiovascular disease; Cholesterol; depression & mood disorders; Diabetes; Education; Epidemiology; Heart; Hypertension; Longitudinal studies; Marital status; Mental depression; Mental Health; Middle age; Older people; Patients; Personal health; Questionnaires; Sensitivity analysis; Statistical analysis; Stroke; Variables; China; depression & mood disorders; mental health; cardiology
• ISSN: 2044-6055; 2044-6055
• DOI: 10.1136/bmjopen-2022-071175

ObjectiveDepressive symptoms and cardiovascular diseases (CVDs) are important issues affecting the health of the middle-aged and elderly population in China. This study aimed to investigate the bidirectional association between depressive symptoms and CVD in middle-aged and elderly people in China.DesignA 5-year longitudinal study.Setting and participantsWe included 6702 middle-aged and elderly participants from China Health and Retirement Longitudinal Study (CHARLS), which is a nationwide longitudinal household survey that started in 2011 (T1) and followed up every 2 years in 2013 (T2) and 2015 (T3).Outcome measuresDepressive symptoms were measured by the Center for Epidemiological Studies Depression Scale. Binary logistic regression was used to identify the influencing factors of depressive symptoms and CVD at T1. The cross-lagged panel model was used to analyse the association between depressive symptoms and CVD at T1, T2 and T3.ResultsThe CHARLS is a representative longitudinal survey of people aged ≥45 years. Using data extracted from the CHARLS, overall, at T1, 2621 (39.10%) participants had depressive symptoms and 432 (6.4%) had CVD, and at T3, 2423 (36.2%) had depressive symptoms and 760 (11.3%) had CVD, respectively. Depressive symptoms at T1 had a effect on CVD at T2 (β=0.015, p=0.009), and depressive symptoms at T2 had an effect on CVD at T3 (β=0.015, p=0.034). CVD at T1 predicted depressive symptoms at T2 (β=0.036, p=0.002).ConclusionsThere is a bidirectional predictive effect between depressive symptoms and CVD. The effect of depressive symptoms on CVD is stable, and CVD has an effect on depressive symptoms in a short period of time.