Diagnostic and prognostic factors in patients with prostate cancer: a systematic review protocol

IntroductionAs part of the PIONEER (Prostate Cancer Diagnosis and Treatment Enhancement Through the Power of Big Data in Europe) Consortium, we will explore which diagnostic and prognostic factors (DPFs) are currently being researched to previously defined clinical and patient-reported outcomes for...

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Published inBMJ open Vol. 11; no. 2; p. e040531
Main Authors Beyer, Katharina, Moris, Lisa, Lardas, Michael, Haire, Anna, Barletta, Francesco, Scuderi, Simone, Vradi, Eleni, Gandaglia, Giorgio, Omar, Muhammad Imran, MacLennan, Steven, Zong, Jihong, Farahmand, Bahman, Maclennan, Sara J, Devecseri, Zsuzsanna, Asiimwe, Alex, Collette, Laurence, Bjartell, Anders, Ndow, James, Briganti, Alberto, Van Hemelrijck, Mieke
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group LTD 11.02.2021
BMJ Publishing Group
SeriesProtocol
Subjects
Bias
Big Data
Biomarkers
Cancer therapies
Clinical medicine
English language
Europe
Evidence-based medicine
Hogs
Humans
Male
Medical diagnosis
Medical prognosis
Metastasis
Patients
Prognosis
Prostate cancer
Prostatic Neoplasms - diagnosis
Search strategies
Systematic review
Systematic Reviews as Topic
Urology
Europe
urological tumours
oncology
prostate disease
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Summary:IntroductionAs part of the PIONEER (Prostate Cancer Diagnosis and Treatment Enhancement Through the Power of Big Data in Europe) Consortium, we will explore which diagnostic and prognostic factors (DPFs) are currently being researched to previously defined clinical and patient-reported outcomes for prostate cancer (PCa).Methods and analysisThis research project will follow the following four steps: (1) a broad systematic literature review of DPFs for all stages of PCa, covering evidence from 2014 onwards; (2) discussion of systematic review findings by a multidisciplinary expert panel; (3) risk of bias assessment and applicability with Prediction model Risk Of Bias Assessment Tool criteria, Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) and the Quality In Prognosis Studies tool (QUIPS) and (4) additional quantitative assessments if required.Ethics and disseminationWe aim to develop an online tool to present the DPFs identified in this research and make them available across all stakeholders. There are no ethical implications.
Bibliography:ObjectType-Article-1
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ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2020-040531