Impact of valve morphology, hypertension and age on aortic wall properties in patients with coarctation: a two-centre cross-sectional study

• Published in: BMJ open Vol. 10; no. 3; p. e034853
• Main Authors: Ghorbani, Niky, Muthurangu, Vivek, Khushnood, Abbas, Goubergrits, Leonid, Nordmeyer, Sarah, Fernandes, Joao Filipe, Lee, Chong-Bin, Runte, Kilian, Roth, Sophie, Schubert, Stephan, Kelle, Sebastian, Berger, Felix, Kuehne, Titus, Kelm, Marcus
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 25.03.2020; BMJ Publishing Group
• Series: Original research
• Subjects: Adolescent; Adult; Adults; Age groups; Aging - pathology; Antihypertensives; Aorta - pathology; Aortic Coarctation - epidemiology; Aortic Coarctation - pathology; Bicuspid Aortic Valve Disease - epidemiology; Bicuspid Aortic Valve Disease - pathology; Blood pressure; Cardiology; Cardiovascular disease; Cardiovascular Medicine; Congenital diseases; Coronary vessels; Cross-Sectional Studies; Echocardiography; Female; Heart; Humans; Hypertension; Hypertension - epidemiology; Hypertension - pathology; Male; Morphology; Pediatrics; Pulmonary arteries; Teenagers; Young Adult; congenital heart disease; valvular heart disease; paediatric cardiology; hypertension
• ISSN: 2044-6055; 2044-6055
• DOI: 10.1136/bmjopen-2019-034853

ObjectiveWe aimed to investigate the combined effects of arterial hypertension, bicuspid aortic valve disease (BAVD) and age on the distensibility of the ascending and descending aortas in patients with aortic coarctation.DesignCross-sectional study.SettingThe study was conducted at two university medical centres, located in Berlin and London.ParticipantsA total of 121 patients with aortic coarctation (ages 1–71 years) underwent cardiac MRI, echocardiography and blood pressure measurements.Outcome measuresCross-sectional diameters of the ascending and descending aortas were assessed to compute aortic area distensibility. Findings were compared with age-specific reference values. The study complied with the Strengthening the Reporting of Observational Studies in Epidemiology statement and reporting guidelines.ResultsImpaired distensibility (below fifth percentile) was seen in 37% of all patients with coarctation in the ascending aorta and in 43% in the descending aorta. BAVD (43%) and arterial hypertension (72%) were present across all ages. In patients >10 years distensibility impairment of the ascending aorta was predominantly associated with BAVD (OR 3.1, 95% CI 1.33 to 7.22, p=0.009). Distensibility impairment of the descending aorta was predominantly associated with arterial hypertension (OR 2.8, 95% CI 1.08 to 7.2, p=0.033) and was most pronounced in patients with uncontrolled hypertension despite antihypertensive treatment.ConclusionFrom early adolescence on, both arterial hypertension and BAVD have a major impact on aortic distensibility. Their specific effects differ in strength and localisation (descending vs ascending aorta). Moreover, adequate blood pressure control is associated with improved distensibility. These findings could contribute to the understanding of cardiovascular complications and the management of patients with aortic coarctation.