COVID-19 outcomes in UK centre within highest health and wealth band: a prospective cohort study

• Published in: BMJ open Vol. 10; no. 11; p. e042090
• Main Authors: Ken-Dror, Gie, Wade, Charles, Sharma, Shyam, Law, Jessica, Russo, Cristina, Sharma, Aarti, Joy, Elizabeth, John, Joshua, Robin, Jonathan, John, Sarah, Mahana, Karim, Fluck, David, Bentley, Paul, Sharma, Pankaj
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 16.11.2020; BMJ Publishing Group
• Series: Original research
• Subjects: Aged; Aged, 80 and over; Asthma; Cohort analysis; Coronaviruses; COVID-19; COVID-19 - epidemiology; Dementia; Diabetes; Disease transmission; Epidemiology; Female; Health care; Hospital Mortality - trends; Hospitalization - trends; Humans; Infections; Inpatients; Intensive Care; Intensive Care Units; Liver diseases; Male; Medical prognosis; Mortality; Obesity; Pandemics; Patients; Prospective Studies; Public health; Regions; Risk Factors; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; United Kingdom - epidemiology; Variables; United Kingdom; United Kingdom > UK; COVID-19; epidemiology; public health
• ISSN: 2044-6055; 2044-6055
• DOI: 10.1136/bmjopen-2020-042090

ObjectivesTo describe the characteristics and outcomes of hospitalised patients with COVID-19 from UK in the highest decile of health and gross regional products per capita.DesignProspective cohort study.SettingRecruited all adult inpatients with laboratory-confirmed COVID-19 symptoms admitted to a single Surrey centre between March and April 2020. Extensive demographic details were documented.Outcome measureCOVID-19 status of alive/dead and intensive care unit (ICU) status of yes/no.ParticipantsPatients with COVID-19 from Surrey centre UK (n=429).Results429 adult inpatients (mean age 70±18 years; men 56.4%) were included in this study, of whom, 19.1% required admission to ICU and 31.9% died. Adverse outcomes were associated with age (OR with each decade of years: 1.78, 95% CI 1.53 to 2.11, p<0.001 for mortality); male gender (OR=1.08, 95% CI 0.72 to 1.63, p=0.72, present in 70.7%, of admissions to ICU versus 53% of other cases, p=0.004); cardiac disease (OR=3.43, 95% CI 2.10 to 5.63, p<0.001), diabetes mellitus (OR=2.37, 95% CI 1.09 to 5.17, p=0.028) and dementia (OR=5.06, 95% CI 2.79 to 9.44, p<0.001). There was no significant impact of ethnicity or body mass index on disease outcome.ConclusionsDespite reports of worse outcomes in deprived regions, we show similar complication and mortality rates due to COVID-19 in an affluent and high life expectancy region.