Felty's syndrome associated with high levels of IgA rheumatoid factor

A 64-year-old woman with rheumatoid arthritis developed Felty's syndrome. Her serum contained large amounts of IgA rheumatoid factor (RF) but insignificant levels of IgM-RF and IgG-RF. It is postulated that the high levels of IgA-RF may have contributed to the neutropenia.

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Bibliographic Details
Published inAnnals of the rheumatic diseases Vol. 43; no. 3; pp. 505 - 507
Main Authors Withrington, R H, Teitsson, I, Seifert, M H, Valdimarsson, H
Format Journal Article
LanguageEnglish
Published London BMJ Publishing Group Ltd and European League Against Rheumatism 01.06.1984
BMJ
BMJ Publishing Group LTD
Subjects
Biological and medical sciences
Diseases of the osteoarticular system
Enzyme-Linked Immunosorbent Assay
Felty Syndrome - complications
Felty Syndrome - immunology
Female
Humans
Immunoglobulin A - analysis
Inflammatory joint diseases
Medical sciences
Middle Aged
Neutropenia - etiology
Rheumatoid Factor - analysis
Rheumatoid factor
Chronic
IgA
Inflammatory joint disease
Felty syndrome
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Summary:A 64-year-old woman with rheumatoid arthritis developed Felty's syndrome. Her serum contained large amounts of IgA rheumatoid factor (RF) but insignificant levels of IgM-RF and IgG-RF. It is postulated that the high levels of IgA-RF may have contributed to the neutropenia.
Bibliography:href:annrheumdis-43-505.pdf
PMID:6742912
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ISSN:0003-4967
1468-2060
DOI:10.1136/ard.43.3.505