The in vitro activity of fatty diamines and amino alcohols against mixed amastigote and trypomastigote Trypanosoma cruzi forms
Four diamines and three amino alcohols derived from 1-decanol, 1-dodecanol and 1,2-dodecanediol were evaluated in an in vitro assay against a mixture of trypomastigote and intracellular amastigote forms of Trypanosoma cruzi . Two of these compounds (6 and 7) showed better activity against both proli...
Saved in:
Published in | Memórias do Instituto Oswaldo Cruz Vol. 109; no. 3; pp. 362 - 364 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English Portuguese |
Published |
Brazil
Fundação Oswaldo Cruz, Fiocruz
01.06.2014
Instituto Oswaldo Cruz, Ministério da Saúde Fundação Oswaldo Cruz (FIOCRUZ) |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Four diamines and three amino alcohols derived from 1-decanol,
1-dodecanol and 1,2-dodecanediol were evaluated in an in vitro assay
against a mixture of trypomastigote and intracellular amastigote forms
of Trypanosoma cruzi . Two of these compounds (6 and 7) showed better
activity against both proliferative stages of T. cruzi than the
positive control benznidazole, three were of similar potency (1, 2 and
5) and two were less active (3 and 4). |
---|---|
ISSN: | 1678-8060 0074-0276 1678-8060 |
DOI: | 10.1590/0074-0276130496 |