The in vitro activity of fatty diamines and amino alcohols against mixed amastigote and trypomastigote Trypanosoma cruzi forms

Four diamines and three amino alcohols derived from 1-decanol, 1-dodecanol and 1,2-dodecanediol were evaluated in an in vitro assay against a mixture of trypomastigote and intracellular amastigote forms of Trypanosoma cruzi . Two of these compounds (6 and 7) showed better activity against both proli...

Full description

Saved in:
Bibliographic Details
Published inMemórias do Instituto Oswaldo Cruz Vol. 109; no. 3; pp. 362 - 364
Main Authors Júnior, Policarpo Ademar Sales, Júnior, Celso Oliveira Rezende, Le Hyaric, Mireille, de Almeida, Mauro Vieira, Romanha, Alvaro José
Format Journal Article
LanguageEnglish
Portuguese
Published Brazil Fundação Oswaldo Cruz, Fiocruz 01.06.2014
Instituto Oswaldo Cruz, Ministério da Saúde
Fundação Oswaldo Cruz (FIOCRUZ)
Subjects
amino alcohols
Amino Alcohols - pharmacology
Chagas disease
diamines
Diamines - pharmacology
Dose-Response Relationship, Drug
lipophilicity
Parasitic Sensitivity Tests
PARASITOLOGY
TROPICAL MEDICINE
Trypanocidal Agents - pharmacology
Trypanosoma cruzi
Trypanosoma cruzi - drug effects
Chagas disease
lipophilicity
amino alcohols
Trypanosoma cruzi
diamines
Online AccessGet full text

Cover

More Information
Summary:Four diamines and three amino alcohols derived from 1-decanol, 1-dodecanol and 1,2-dodecanediol were evaluated in an in vitro assay against a mixture of trypomastigote and intracellular amastigote forms of Trypanosoma cruzi . Two of these compounds (6 and 7) showed better activity against both proliferative stages of T. cruzi than the positive control benznidazole, three were of similar potency (1, 2 and 5) and two were less active (3 and 4).
ISSN:1678-8060
0074-0276
1678-8060
DOI:10.1590/0074-0276130496