Type-3c Diabetes Mellitus, Diabetes of Exocrine Pancreas - An Update

• Published in: Current diabetes reviews Vol. 15; no. 5; p. 382
• Main Authors: Bhattamisra, Subrat Kumar, Siang, Tiew Chin, Rong, Chieng Yi, Annan, Naveenya Chetty, Sean, Esther Ho Yung, Xi, Lim Wen, Lyn, Ong Siu, Shan, Liew Hui, Choudhury, Hira, Pandey, Manisha, Gorain, Bapi
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2019
• Subjects: Diabetes Mellitus - diagnosis; Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - therapy; Humans; Insulin; Pancreas - physiopathology; Pancreas, Exocrine - physiopathology; Pancreatic Diseases - diagnosis; Pancreatic Diseases - therapy; Pancreatitis, Chronic - physiopathology; Type 3c diabetes mellitus; glucagon; chronic pancreatitis; pancreatogenic diabetes; insulin; pancreatic ductal adenocarcinoma
• ISSN: 1875-6417
• DOI: 10.2174/1573399815666190115145702

The incidence of diabetes is increasing steeply; the number of diabetics has doubled over the past three decades. Surprisingly, the knowledge of type 3c diabetes mellitus (T3cDM) is still unclear to the researchers, scientist and medical practitioners, leading towards erroneous diagnosis, which is sometimes misdiagnosed as type 1 diabetes mellitus (T1DM), or more frequently type 2 diabetes mellitus (T2DM). This review is aimed to outline recent information on the etiology, pathophysiology, diagnostic procedures, and therapeutic management of T3cDM patients. The literature related to T3cDM was thoroughly searched from the public domains and reviewed extensively to construct this article. Further, existing literature related to the other forms of diabetes is reviewed for projecting the differences among the different forms of diabetes. Detailed and updated information related to epidemiological evidence, risk factors, symptoms, diagnosis, pathogenesis and management is structured in this review. T3cDM is often misdiagnosed as T2DM due to the insufficient knowledge differentiating between T2DM and T3cDM. The pathogenesis of T3cDM is explained which is often linked to the history of chronic pancreatitis, pancreatic cancer. Inflammation, and fibrosis in pancreatic tissue lead to damage both endocrine and exocrine functions, thus leading to insulin/glucagon insufficiency and pancreatic enzyme deficiency. Future advancements should be accompanied by the establishment of a quick diagnostic tool through the understanding of potential biomarkers of the disease and newer treatments for better control of the diseased condition.