Merozoite surface protein 2 allelic variation influences the specific antibody response during acute malaria in individuals from a Brazilian endemic area

• Published in: Memórias do Instituto Oswaldo Cruz Vol. 102; no. 3; pp. 421 - 424
• Main Authors: Sallenave-Sales, Selma, Faria, Clarissa Perez, Zalis, Mariano Gustavo, Daniel-Ribeiro, Cláudio Tadeu, Ferreira-da-Cruz, Maria de Fátima
• Format: Journal Article
• Language: English; Portuguese
• Published: Brazil Fundação Oswaldo Cruz, Fiocruz 01.06.2007; Instituto Oswaldo Cruz, Ministério da Saúde; Fundação Oswaldo Cruz (FIOCRUZ)
• Subjects: Acute Disease; Adult; Alleles; Animals; Antibodies, Protozoan - blood; Antibodies, Protozoan - immunology; antibody response; antibody response - antigenic polymorphism; Antibody Specificity; antigenic polymorphism; Antigens, Protozoan - genetics; Antigens, Protozoan - immunology; Brazil - epidemiology; Endemic Diseases; Enzyme-Linked Immunosorbent Assay; Humans; Immunoglobulin G - blood; Immunoglobulin G - immunology; malaria; Malaria, Falciparum - epidemiology; Malaria, Falciparum - immunology; Malaria, Falciparum - parasitology; merozoite surface protein-2; Middle Aged; PARASITOLOGY; Plasmodium falciparum; Plasmodium falciparum - genetics; Plasmodium falciparum - immunology; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Single-Stranded Conformational; Protozoan Proteins - genetics; Protozoan Proteins - immunology; TROPICAL MEDICINE; Brazil; Plasmodium falciparum; antibody response; merozoite surface protein-2; malaria; antigenic polymorphism
• ISSN: 1678-8060; 0074-0276; 1678-8060
• DOI: 10.1590/S0074-02762007005000048

The antibody response to Plasmodium falciparum parasites of naturally infected population is critical to elucidate the role of polymorphic alleles in malaria. Thus, we evaluated the impact of antigenic diversity of repetitive and family dimorphic domains of the merozoite surface protein 2 (MSP-2) on immune response of 96 individuals living in Peixoto de Azevedo (MT-Brazil), by ELISA using recombinant MSP-2 proteins. The majority of these individuals were carrying FC27-type infections. IgG antibody responses were predominantly directed to FC27 parasites and were correlated to the extension of polymorphism presented by each MSP-2 region. This finding demonstrated the impact of the genetic polymorphism on antibody response and therefore, its importance on malaria vaccine efficacy.