Prevalence and level of antibodies to the circumsporozoite protein of human malaria parasites in five states of the Amazon region of Brazil
The aim of this study was to determine the prevalence of malaria infection and antibodies against the repetitive epitopes of the circumsporozoite (CS) proteins of Plasmodium falciparum, P. malariae, P. vivax VK210, P. vivax VK247, and P. vivax-like in individuals living in the states of Rondônia, Pa...
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Published in | Memórias do Instituto Oswaldo Cruz Vol. 102; no. 3; pp. 367 - 371 |
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Main Authors | , , , |
Format | Journal Article |
Language | English Portuguese |
Published |
Brazil
Fundação Oswaldo Cruz, Fiocruz
01.06.2007
Instituto Oswaldo Cruz, Ministério da Saúde Fundação Oswaldo Cruz (FIOCRUZ) |
Subjects | |
Online Access | Get full text |
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Summary: | The aim of this study was to determine the prevalence of malaria
infection and antibodies against the repetitive epitopes of the
circumsporozoite (CS) proteins of Plasmodium falciparum, P. malariae,
P. vivax VK210, P. vivax VK247, and P. vivax-like in individuals living
in the states of Rondônia, Pará, Mato Grosso, Amazonas, and
Acre. Active malaria transmission was occurring in all studied sites,
except in Acre. P. falciparum was the predominant species in Pará
and Rondônia and P. vivax in Mato Grosso. Infection by P. malariae
was low but this Plasmodium species was detected in Rondônia
(3.5%), Mato Grosso (2.5%), and Pará (0.8%). High prevalence and
levels of serological reactivity against the CS repeat peptides of P.
falciparum were detected in Rondônia (93%) and Pará (85%).
Sera containing antibodies against the CS repeat of P. malariae
occurred more frequently in Rondônia (79%), Pará (76%), and
Amazonas (68%). Antibodies against the repeat epitope of the standard
CS protein of P. vivax VK210, P. vivax VK247, and P. vivax-like were
more frequent in Rondônia, Pará, and Mato Grosso. The high
frequency of reactions to P. malariae in most of the areas suggests
that the infection by this Plasmodium species has been underestimated
in Brazil. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1678-8060 0074-0276 1678-8060 |
DOI: | 10.1590/S0074-02762007005000041 |