Bimodal gene expression patterns in breast cancer

We identified a set of genes with an unexpected bimodal distribution among breast cancer patients in multiple studies. The property of bimodality seems to be common, as these genes were found on multiple microarray platforms and in studies with different end-points and patient cohorts. Bimodal genes...

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Bibliographic Details
Published inBMC genomics Vol. 11 Suppl 1; no. S1; p. S8
Main Authors Bessarabova, Marina, Kirillov, Eugene, Shi, Weiwei, Bugrim, Andrej, Nikolsky, Yuri, Nikolskaya, Tatiana
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 10.02.2010
BioMed Central
BMC
Subjects
Biometric Identification
Breast Neoplasms - genetics
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
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Summary:We identified a set of genes with an unexpected bimodal distribution among breast cancer patients in multiple studies. The property of bimodality seems to be common, as these genes were found on multiple microarray platforms and in studies with different end-points and patient cohorts. Bimodal genes tend to cluster into small groups of four to six genes with synchronised expression within the group (but not between the groups), which makes them good candidates for robust conditional descriptors. The groups tend to form concise network modules underlying their function in cancerogenesis of breast neoplasms.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:1471-2164
1471-2164
DOI:10.1186/1471-2164-11-S1-S8