Overview of molecular mechanisms involved in herbal compounds for inhibiting osteoclastogenesis from macrophage linage RAW264.7

Differentiation from RAW264.7 cells to osteoclasts rely on many signaling pathways, such as NF-κB, MAPK, Akt and others. However, the specific underlying mechanisms are not clear. Recently, much works have focused on the inhibitory effects of plant derived compounds in the differentiation from RAW26...

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Bibliographic Details
Published inCurrent stem cell research & therapy
Main Authors He, Gaole, Ma, Rui
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.01.2020
Subjects
Plant derived compounds
signaling pathway
RAW264.7
osteoclasts
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Summary:Differentiation from RAW264.7 cells to osteoclasts rely on many signaling pathways, such as NF-κB, MAPK, Akt and others. However, the specific underlying mechanisms are not clear. Recently, much works have focused on the inhibitory effects of plant derived compounds in the differentiation from RAW264.7 to osteoclasts. However, the specific mechanisms remain unclear. In this paper, we summarize a lot of plant derived compounds which exert blocking effect on the progression of differentiation via signaling pathways.
ISSN:2212-3946
DOI:10.2174/1574888X14666190703144917