Apatinib plus camrelizumab (anti-PD1 therapy, SHR-1210) for advanced osteosarcoma (APFAO) progressing after chemotherapy: a single-arm, open-label, phase 2 trial

• Published in: Journal for immunotherapy of cancer Vol. 8; no. 1; p. e000798
• Main Authors: Xie, Lu, Xu, Jie, Sun, Xin, Guo, Wei, Gu, Jin, Liu, Kuisheng, Zheng, Bingxin, Ren, Tingting, Huang, Yi, Tang, Xiaodong, Yan, Taiqiang, Yang, Rongli, Sun, Kunkun, Shen, Danhua, Li, Yuan
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.05.2020; BMJ Publishing Group
• Subjects: Antibodies; Bone cancer; Cancer; Chemotherapy; Clinical/Translational Cancer Immunotherapy; Drug dosages; Hypotheses; Immunotherapy; Inhibitor drugs; Metastasis; Monoclonal antibodies; Patients; Quality of life; Response rates; Sarcoma; Targeted cancer therapy; Tumors; drug therapy, combination; immunohistochemistry; clinical trials, phase II as topic; pediatrics; biomarkers, tumor
• ISSN: 2051-1426; 2051-1426
• DOI: 10.1136/jitc-2020-000798

BackgroundResults of our previous study showed high objective response but short-term activity of apatinib in advanced osteosarcoma. We aimed to investigate the activity of apatinib in combination with camrelizumab in patients with inoperable high-grade osteosarcoma progressing after chemotherapy.MethodsThis open-label, phase 2 trial was conducted at Peking University People’s Hospital. We enrolled patients with advanced osteosarcoma progressed after chemotherapy. Patients received 500 mg apatinib orally once daily plus 200 mg camrelizumab by intravenous infusion every 2 weeks until disease progression or unacceptable toxicity. The primary endpoint was progression-free survival (PFS) and clinical benefit rate at 6 months, which were based on RECIST V.1.1.Results43 patients were enrolled between January 25 and September 4, 2018. With median follow-up time of 48.3 (Q1, Q3, 30.6, 66.6) weeks, 13 (30.23%, 95% CI 17.2%, 40.1%) of 43 patients were progression free at 6 months and the 6-month PFS rate was 50.9% (95% CI 34.6%, 65.0%). Until final follow-up, the objective response rate was 20.9% (9/43) and two patients with durable disease control were observed. Patients with programmed cell death 1 ligand-1 (PD-L1) tumor proportion score ≥5% and pulmonary metastases tended to have a longer PFS in comparison to the others (p=0.004 and 0.017, respectively). Toxic effects led to dose reductions, or interruptions, or both in 24 (55.8%) of 43 patients and permanent discontinuation in 4 (9.3%) patients. There were no treatment-related deaths.ConclusionsAlthough the combination of apatinib and camrelizumab seemed to prolong PFS in comparison to single agent apatinib in treating advanced osteosarcoma, it did not reach the prespecified target of 6-month PFS of 60% or greater. Overexpression of PD-L1 and the presence of pulmonary metastases only were associated with longer PFS.Trial registration numberNCT03359018.