Efficacy of fluoroquinolones against pathogenic oral bacteria

This article reviews the characteristics of the main fluoroquinolones used in dentistry (ciprofloxacin, levofloxacin and moxifloxacin), including pharmacokinetic/ pharmacodynamic parameters, susceptibility profiles of oral bacteria and clinical trials on their efficacy in dental practice. It seems t...

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Bibliographic Details
Published inMini reviews in medicinal chemistry Vol. 9; no. 10; p. 1147
Main Authors Núñez Otero, V, Limeres Posse, J, Carmona, I Tomás, Diz Dios, P
Format Journal Article
LanguageEnglish
Published Netherlands 01.09.2009
Subjects
Aza Compounds - chemistry
Aza Compounds - pharmacokinetics
Aza Compounds - pharmacology
Aza Compounds - therapeutic use
Bacteria - drug effects
Bacterial Infections - drug therapy
Ciprofloxacin - chemistry
Ciprofloxacin - pharmacokinetics
Ciprofloxacin - pharmacology
Ciprofloxacin - therapeutic use
Fluoroquinolones - chemistry
Fluoroquinolones - pharmacokinetics
Fluoroquinolones - pharmacology
Fluoroquinolones - therapeutic use
Humans
Levofloxacin
Mouth Diseases - drug therapy
Ofloxacin - chemistry
Ofloxacin - pharmacokinetics
Ofloxacin - pharmacology
Ofloxacin - therapeutic use
Oral Medicine
Quinolines - chemistry
Quinolines - pharmacokinetics
Quinolines - pharmacology
Quinolines - therapeutic use
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Summary:This article reviews the characteristics of the main fluoroquinolones used in dentistry (ciprofloxacin, levofloxacin and moxifloxacin), including pharmacokinetic/ pharmacodynamic parameters, susceptibility profiles of oral bacteria and clinical trials on their efficacy in dental practice. It seems that some of these antibiotics might represent a safe alternative in patients with allergy, intolerance, or lack of response to beta-lactams.
ISSN:1389-5575
DOI:10.2174/138955709789055243