Primary meningeal T-cell lymphoma in a harbor seal (Phoca vitulina)

A 15-year-old female harbor seal (Phoca vitulina) was referred to the Nantes Veterinary School, Nantes, France, with a clinical history of anorexia, seizures, and left hemiplegia. Cerebrospinal fluid analysis revealed large numbers of neoplastic lymphoid cells. After injection of a contrast agent in...

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Bibliographic Details
Published inJournal of zoo and wildlife medicine Vol. 38; no. 2; p. 323
Main Authors Labrut, Sophie, Wyers, Monique, Miclard, Julien, Colle, Marie-Anne
Format Journal Article
LanguageEnglish
Published United States 01.06.2007
Subjects
Animals
Diagnosis, Differential
Fatal Outcome
Female
Immunohistochemistry - veterinary
Lymphoma, T-Cell - diagnosis
Lymphoma, T-Cell - pathology
Lymphoma, T-Cell - veterinary
Meningeal Neoplasms - diagnosis
Meningeal Neoplasms - pathology
Meningeal Neoplasms - veterinary
Phoca
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Summary:A 15-year-old female harbor seal (Phoca vitulina) was referred to the Nantes Veterinary School, Nantes, France, with a clinical history of anorexia, seizures, and left hemiplegia. Cerebrospinal fluid analysis revealed large numbers of neoplastic lymphoid cells. After injection of a contrast agent into the cerebrospinal space, radiographs demonstrated an asymmetry of the right lateral ventricle. Necropsy examination revealed a marked edema of the right frontal lobe, extending to the basal nuclei and thalamus in the brain. Histological examination of the brain revealed leptomeningeal lymphoma. Immunohistochemical labeling demonstrated that the neoplasm was of T-cell origin. No significant macroscopic or microscopic lesions were observed in the other organs examined, including lymphoid organs. This is the first report of primary leptomeningeal lymphoma in a harbor seal.
ISSN:1042-7260
DOI:10.1638/1042-7260(2007)038[0323:PMTLIA]2.0.CO;2