Inflammatory bowel disease stimulates formation of carcinogenic N-nitroso compounds

[...]we collected faecal samples from 17 patients diagnosed with ulcerative colitis and 17 healthy controls, and determined levels of N-nitrosodimethylamine (NDMA), a predominant carcinogenic NOC, using gas chromatography-mass spectrometry, as previously described.).

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Bibliographic Details
Published inGut Vol. 54; no. 5; p. 731
Main Authors de Kok, T M C M, Engels, L G J B, Moonen, E J, Kleinjans, J C S
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.05.2005
BMJ Publishing Group LTD
Copyright 2005 by Gut
Subjects
Carcinogens - metabolism
colon cancer
Colorectal cancer
Colorectal Neoplasms - etiology
Dimethylnitrosamine
Feces - chemistry
Humans
inducible nitric oxide synthase
Inflammatory bowel disease
Inflammatory Bowel Diseases - metabolism
Letter
N -nitrosodimethylamine
N-nitroso compounds
Nitric Oxide Synthase - metabolism
Nitric Oxide Synthase Type II
Nitrosamines - analysis
Nitroso Compounds - metabolism
Rodents
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Summary:[...]we collected faecal samples from 17 patients diagnosed with ulcerative colitis and 17 healthy controls, and determined levels of N-nitrosodimethylamine (NDMA), a predominant carcinogenic NOC, using gas chromatography-mass spectrometry, as previously described.).
Bibliography:ark:/67375/NVC-NGC4JK2H-W
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href:gutjnl-54-731-2.pdf
PMID:15831929
istex:9E2EEC2E90D40FC1008FC56EFA661FAD2982056A
Correspondence to:
 Dr T M C M de Kok
 Department of Health Risk Analysis and Toxicology, University Maastricht, PO Box 616, 6200 MD, Maastricht, the Netherlands; t.dekok@grat.unimaas.nl
ObjectType-Article-1
SourceType-Scholarly Journals-1
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Correspondence to: …Dr T M C M de Kok …Department of Health Risk Analysis and Toxicology, University Maastricht, PO Box 616, 6200 MD, Maastricht, the Netherlands; t.dekok@grat.unimaas.nl
Conflict of interest: None declared.
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.2004.057471