Beneficial effect of short term intake of red wine polyphenols on coronary microcirculation in patients with coronary artery disease

• Published in: Heart (British Cardiac Society) Vol. 92; no. 5; pp. 681 - 682
• Main Authors: Hozumi, T, Sugioka, K, Shimada, K, Kim, S H, Kuo, M Y, Miyake, Y, Fujimoto, K, Otsuka, R, Watanabe, H, Hosoda, K, Yoshikawa, J, Homma, S
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and British Cardiovascular Society 01.05.2006; BMJ; BMJ Publishing Group LTD; BMJ Group
• Subjects: Biological and medical sciences; blood flow; Blood Flow Velocity - drug effects; Blood Flow Velocity - physiology; Body mass index; CAD; Cardiology. Vascular system; Cardiovascular disease; CFV; CFVR; coronary artery disease; Coronary Artery Disease - physiopathology; Coronary Circulation - drug effects; Coronary Circulation - physiology; coronary disease; coronary flow velocity; coronary flow velocity reserve; Coronary heart disease; Coronary vessels; echocardiography; Flavonoids - pharmacology; Flow velocity; Heart; Heart rate; Humans; Male; Medical sciences; microcirculation; Microcirculation - drug effects; Middle Aged; myocardial infarction; Phenols - pharmacology; Polyphenols; Scientific Letter; transthoracic Doppler echocardiography; TTDE; Wine; Wines; New York; Short term; Human; Microcirculation; Polyphenol; Coronary artery; Cardiovascular disease; Circulatory system; Cardiology; Red wine; Coronary heart disease; Phlebology
• ISSN: 1355-6037; 1468-201X
• DOI: 10.1136/hrt.2004.059204

Favourably, in patients with CAD CFVR increased after polyphenol intake up to the level of CFVR in non-CAD subjects before they had taken polyphenols. [...]the present results suggest that a daily intake of red wine polyphenols may benefit both people without CAD and patients with CAD by improving the coronary microcirculation. [...]we obtained no data to suggest the mechanism of reduced CFVR in patients with CAD at baseline, although one possible mechanism may be coronary microcirculation dysfunction probably caused by decreased endothelial function.